In 1970,the first bone substitute-PMMA was created and a lot of clinical studies were conducted.Clinical applications demonstrate good results and the mortality rate of osteomyelitis is significantly reduced.According to the degradation of materials,the drug-delivery system can be divided into biodegradable materials and non-degradable materials.As the bone substitute,the two types of materials were required to achieve the minimum inhibitory concentration in nature.The system types,preparation methods,the nature of the drug,and the drug release kinetics were reviewed.