Journal of Tissue Engineering and Reconstructive Surgery ›› 2012, Vol. 8 ›› Issue (2): 117-120.doi: 10.3969/j.issn.1673-0364.2012.02.016

• Original article • Previous Articles    

Advancement of Drug-Delivery System in the Treatment of Osteomyelitis with Bone Defects

LIU Chen1,Yang Qingsong2,SU Jiacan2   

  1. 1 The Second Military Medical University,Shanghai 200433,China;2 Changhai Hospital,The Second Military Medical University,Shanghai 200433,China.
  • Published:2020-07-23
  • Contact: 上海市人事局人才发展基金　　（2009003）；上海市卫生系统新优青计划　　（2011032）

Abstract: In 1970,the first bone substitute-PMMA was created and a lot of clinical studies were conducted.Clinical applications demonstrate good results and the mortality rate of osteomyelitis is significantly reduced.According to the degradation of materials,the drug-delivery system can be divided into biodegradable materials and non-degradable materials.As the bone substitute,the two types of materials were required to achieve the minimum inhibitory concentration in nature.The system types,preparation methods,the nature of the drug,and the drug release kinetics were reviewed.

Key words: Drug-delivery system, Osteomyelitis, Bone defects, Antibiotic, Growth factor

CLC Number: