Objective To investigate the method and effect of comprehensive treatment of limb-salvage operation of lower limb destructive injury.Methods Summing up the 17 cases of serious lower limb destructive injuries in the past five years,all patients were given emergency surgery within 6-8 hours after injury,including internal or external fixation, anastomosis of damage blood vessels and nerves,first or second flap transplantation.After that comprehensive treatment was performed.Results One case was amputated due to below inguinal multi-vessel laceration and muscular necrosis.The lower limbs of destructive injury were salvaged in 16 cases.Conclusion Application of a reasonable comprehensive surgical treatment can effectively save the verge amputation limb of severe trauma and reduce disability rate.