Journal of Tissue Engineering and Reconstructive Surgery >

2008 , Vol. 4 >Issue 6: 320 - 322

DOI: https://doi.org/10.3969/j.issn.1673-0364.2008.06.006

Original article

Effects of FAK SiRNA On the Expression of Integrinα1,TGF-βR,FAK and α-SMA in Hypertrophic Scar Fibroblasts In Vitro

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  • 1 Department of Plastic Surgery;Renji Hospital;Shanghai Jiaotong University School of Medicine;2 Department of Urology Surgery;Shanghai 200127;China.;

Online published: 2020-07-23

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Abstract

Objective Explore the effects of FAK SiRNA on the expression of integrin α1, TGF-βR, focal adhesive kinase (FAK) and α-smooth muscle actin (α-SMA) of hypertrophic scar fibroblasts. Methods After hypertrophic scar fibroblasts were transfected by FAK SiRNA, FQ-PCR assay was applied to detect the mRNA expression of integrin α1, TGF-βR, FAK, α-SMA. Results 48 hours after transfection the mRNA expression of integrin α1, TGF-βR, FAK, α-SMA was significantly lower than before transfection (P<0.05). Conclusion F...

Key words： Hypertrophic scar; Focal adhesive kinase; Small interfering RNAs （SiRNA）; FQ-PCR

Cite this article

CHEN Rui,FAN Zhihong,FU Mingang,WANG Ling,PING Ping . Effects of FAK SiRNA On the Expression of Integrinα1,TGF-βR,FAK and α-SMA in Hypertrophic Scar Fibroblasts In Vitro[J]. Journal of Tissue Engineering and Reconstructive Surgery, 2008 , 4(6) : 320 -322 . DOI: 10.3969/j.issn.1673-0364.2008.06.006

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