The drill center of subsea production system refers to the subsea wellhead and the surrounding access facilities. The layout design of drill center is an important part of the engineering of subsea production system. It mainly includes subsea wellhead and manifold layout, subsea pipeline approaching layout, flying lead layout, etc. We introduce the principle and design considerations of subsea production system drill center layout. Especially, for a South China Sea gas field, the drill center layout design considerations and design methods are illustrated, embodying the system design rationality.