Chemicals such as methanol and ethylene glycol can prevent the formation of hydrates， waxing and scaling within subsea production systems， playing a crucial role in flow assurance. Subsea Chemical Injection Metering Valve (CIMV) is used to control and measure the injected chemicals into subsea production systems. It aids in achieving precise ondemand injection as well as cost reduction and efficiency increase. The structure and measurement principle of CIMV differ significantly from conventional flow meters， hence rigorous calibration is required to ensure the measurement accuracy meeting the design requirements. Based on the product characteristics of CIMV， this paper introduces the design and construction of the first domestic CIMV calibration loop， and discusses how to use this loop to study and build a selfdeveloped CIMV measurement algorithm model. The measurement accuracy of CIMV is verified on this loop， with results as good as ±3% F.S. (Full Scale). This paper provides a valuable reference for the localization of CIMV.