There exist some common contradictions in experimental teaching in the economics & management majors, such as teaching time reducing, the content updating and increasing, students’ self-study ability decreasing, and lack of laboratory resources utilization. The article chooses ERP courses as the research object, depending on qualitative and quantitative methods, discusses the teaching modes about autonomous learning under the platform of open laboratory, and puts forward proposals about the teaching material selecting, teaching process optimizing, teaching method and evaluation reforming, so as to cultivate students’ self-learning ability, achieve better teaching effect, and resolve conflicts related to the experiment teaching. The results show that the mode is welcomed by almost all the students and improved their self-learning ability, meanwhile, the related data provide qualitative reference for further optimization of the mode.