诊断学理论与实践

诊断学理论与实践 ›› 2018, Vol. 17 ›› Issue (04): 449-452.doi: 10.16150/j.1671-2870.2018.04.018

• 论著 • 上一篇    下一篇

孕妇IgG抗A（抗B）的效价积分对新生儿溶血病贫血严重程度的预判价值

汤伟娴1, 金沙2, 郑皆炜2, 叶珍1, 刘曦2, 沈伟2   

  1. 1.上海市第一妇婴保健院,上海 200040;
    2.上海市血液中心,上海 200051
  • 收稿日期:2018-03-19 出版日期:2018-08-25 发布日期:2018-08-25
  • 通讯作者: 沈伟 E-mail: danielsam@qq.com

The predictive value of IgG anti-A/B titer score on severity of hemolytic disease of newborn

TANG Weixian1, JIN Sha2, ZHENG Jiewei2, YE Zhen1, LIU Xi2, SHEN Wei2   

  1. 1. Shanghai First Maternity and Infant Hospital, Shanghai 200040, China;
    2 Shanghai Blood Center, Shanghai 200051, China
  • Received:2018-03-19 Online:2018-08-25 Published:2018-08-25

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摘要： 目的：探讨采用母亲体内IgG抗A（抗B）的效价积分对新生儿溶血病严重程度进行预判的价值。方法：检测27例新生儿溶血病患儿的红细胞计数、血红蛋白、红细胞比容和其母亲的IgG抗A（抗B）效价、效价积分,对其进行趋势线计算和相关性分析。结果：母亲的IgG抗A（抗B）效价积分和效价上升时,患儿的红细胞计数、血红蛋白含量、红细胞比容都下降;而在母亲抗体效价相同的情况下,效价积分越高,患儿的红细胞计数、血红蛋白含量、红细胞比容越低。相关性分析显示,在对新生儿溶血病患儿的贫血程度的预判中,效价积分与患儿血红蛋白含量间的相关系数为-0.966,其母亲的IgG抗A（抗B）效价积分与患儿贫血程度间的相关性比抗体效价更密切。结论：孕妇IgG抗A（抗B）的效价积分在预判患儿贫血的严重程度中具有一定临床价值。

关键词: 效价, 效价积分, 新生儿溶血病

Abstract: Objective: To study the correlation of IgG anti-A/B titer score and the severity of hemolytic disease of newborn. Methods: The red blood cell count, hemoglobin and hematocrit value of 27 newborn with hemolytic disease and the IgG anti-A/B titer and titer score of their mother were measured and their correlations were analyzed. Results: With the increase in IgG anti-A/B titer and titer score of mother, the red blood cell count, hemoglobin and hematocrit values of newborn with hemolytic disease decreased. At the same IgG anti-A/B titer, the higher the titer score, the lower the red blood count, hemoglobin and hematocrit value were. Conclusions: According to the correlation analysis, the titer score is more closely related to the severity of hemolytic disease of newborn. For hemoglobin, the correlation coefficient was -0.966. The IgG anti-A/B titer score was of more clinical significance in predicting the severity of hemolytic disease in newborn.

Key words: Titer, Titer score, Hemolytic disease of newborn

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