首发精神分裂症患者的视觉工作记忆缺陷相关研究

doi:10.16150/j.1671-2870.2019.01.020

诊断学理论与实践 ›› 2019, Vol. 18 ›› Issue (1): 98-103.doi: 10.16150/j.1671-2870.2019.01.020

首发精神分裂症患者的视觉工作记忆缺陷相关研究

李璇子¹, 佘生林¹, 宗昆仑¹, 毕泰勇², 郑英君¹()

1. 广州医科大学附属脑科医院（广州市惠爱医院）成人精神科，广东广州 510370
2. 重庆西南大学心理学部认知与人格教育部重点实验室，重庆 400715

收稿日期:2019-01-24 出版日期:2019-02-25 发布日期:2019-02-25
通讯作者: 郑英君 E-mail:brainzheng@163.com
基金资助:
国家自然科学基金面上项目(81671334)

Study on visual working memory deficit in patients with first-episode schizophrenia

LI Xuanzi¹, SHE Shenglin¹, ZONG Kunlun¹, BI Taiyong², ZHENG Yingjun¹()

1. Department of Psychiatry, The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangdong Guangzhou 510370, China
2. Faculty of Psychology, Southwest University, Chongqing, Chongqing 400715, China

Received:2019-01-24 Online:2019-02-25 Published:2019-02-25
Contact: ZHENG Yingjun E-mail:brainzheng@163.com

摘要/Abstract

摘要： 目的探讨首发精神分裂症患者是否普遍存在视觉工作记忆缺陷，其损伤性质如何，是否与刺激、症状学及社会功能评分相关，同时分析其在精神分裂症早期诊断中的作用。方法纳入首发精神分裂症患者和正常对照者各18例，进行2项视觉搜索任务，分别是面孔和物品（房子）搜索，比较2组被试者的正确率和反应时。结果精神分裂症患者搜索面孔和房子的反应时与正确率受损程度相当（P<0.01），其工作记忆缺陷独立于记忆负荷，且与病程、药物治疗剂量或症状严重程度无关（P均>0.4）。结论首发精神分裂症患者的视觉工作记忆缺陷与刺激及记忆负荷可能无关。

关键词: 视觉工作记忆, 视觉搜索, 面孔认知, 首发精神分裂症

Abstract:

Objective: Working memory deficit has been found in people with schizophrenia and is thought to be a core cognitive dysfunction. However, little is known that whether the working memory deficits are different in working memory tasks using different stimuli. Methods: In the current study, a typical match-to-sample task was adopted to exa-mine the visual working memory in first-episode schizophrenic patients(n=18) and healthy controls(n=18). Face and house were used as the stimuli and the memory load was manipulated. Results: As face processing has been shown to be impaired in schizophrenia, it was hypothesized that the deficit is more severe in face working memory task than that in house working memory task. However, the results showed an equivalent amount of deficits in face and house working memory task. In addition, the working memory deficit was also independent of the memory load and had no relationship with the duration of illness, the medication, or the schizophrenic symptoms. Conclusions: These results imply that the working memory deficit in schizophrenia is independent of the stimuli.

Key words: First-episode schizophrenia, Visual workingmemory, Face perception, Schizophrenic symptoms

中图分类号:

R749.3

李璇子, 佘生林, 宗昆仑, 毕泰勇, 郑英君. 首发精神分裂症患者的视觉工作记忆缺陷相关研究[J]. 诊断学理论与实践, 2019, 18(1): 98-103.

LI Xuanzi, SHE Shenglin, ZONG Kunlun, BI Taiyong, ZHENG Yingjun. Study on visual working memory deficit in patients with first-episode schizophrenia[J]. Journal of Diagnostics Concepts & Practice, 2019, 18(1): 98-103.

图/表 7

图1

表1

表2

图2

表3

表4

表5

参考文献 17

[1]	Lee J, Park S. Working memory impairments in schizophrenia: a meta-analysis[J]. J Abnorm Psychol, 2005, 114(4):599-611.
[2]	Forbes NF, Carrick LA, McIntosh AM, et al. Working memory in schizophrenia: a meta-analysis[J]. Psychol Med, 2009, 39(6):889-905.
[3]	Johnson MK, McMahon RP, Robinson BM, et al. The relationship between working memory capacity and broad measures of cognitive ability in healthy adults and people with schizophrenia[J]. Neuropsychology, 2013, 27(2):220-229.
[4]	Glahn DC, Ragland JD, Abramoff A, et al. Beyond hypofrontality: a quantitative meta-analysis of functional neuroimaging studies of working memory in schizophrenia[J]. Hum Brain Mapp, 2005, 25(1):60-69.
[5]	Eich TS, Nee DE, Insel C, et al. Neural correlates of impaired cognitive control over working memory in schizophrenia[J]. Biol Psychiatry, 2014, 76(2):146-153.
[6]	Bittner RA, Linden DE, Roebroeck A, et al. The When and Where of Working Memory Dysfunction in Early-Onset Schizophrenia-A Functional Magnetic Resonance Imaging Study[J]. Cereb Cortex, 2015, 25(9):2494-2506.
[7]	Wheeler AL, Chakravarty MM, Lerch JP, et al. Disrupted prefrontal interhemispheric structural coupling in schizophrenia related to working memory performance[J]. Schizophr Bull, 2014, 40(4):914-924.
[8]	Senkowski D, Gallinat J. Dysfunctional prefrontal gamma-band oscillations reflect working memory and other cognitive deficits in schizophrenia[J]. Biol Psychiatry, 2015, 77(12):1010-1019.
[9]	Martin F, Baudouin JY, Tiberghien G, et al. Processing emotional expression and facial identity in schizophrenia[J]. Psychiatry Res, 2005, 134(1):43-53.
[10]	Bortolon C, Capdevielle D, Raffard S. Face recognition in schizophrenia disorder: A comprehensive review of behavioral, neuroimaging and neurophysiological studies[J]. Neurosci Biobehav Rev, 2015, 53:79-107.
[11]	Quintana J, Wong T, Ortiz-Portillo E, et al. Right lateral fusiform gyrus dysfunction during facial information processing in schizophrenia[J]. Biol Psychiatry, 2003, 53(12):1099-1112.
[12]	Onitsuka T, Niznikiewicz MA, Spencer KM, et al. Functional and structural deficits in brain regions subserving face perception in schizophrenia[J]. Am J Psychiatry, 2006, 163(3):455-462.
[13]	Kay SR, Fiszbein A, Opler LA. The positive and negative syndrome scale (PANSS) for schizophrenia[J]. Schizophr Bull, 1987, 13(2):261-276.
[14]	Morosini PL, Magliano L, Brambilla L, et al. Development, reliability and acceptability of a new version of the DSM-Ⅳ Social and Occupational Functioning Assessment Scale (SOFAS) to assess routine social functioning[J]. Acta Psychiatr Scand, 2000, 101(4):323-329.
[15]	龚栩, 黄宇霞, 王妍, 等. 中国面孔表情图片系统的修订[J]. 中国心理卫生杂志, 2011, 25(1):40-46.
[16]	Smith EE, Eich TS, Cebenoyan D, et al. Intact and impaired cognitive-control processes in schizophrenia[J]. Schizophr Res, 2011, 126(1-3):132-137.
[17]	Pirkola T, Tuulio-Henriksson A, Glahn D, et al. Spatial working memory function in twins with schizophrenia and bipolar disorder[J]. Biol Psychiatry, 2005, 58(12):930-936.

项目	SZ组(n=18)	对照组(n=18)	t值	P值
年龄（岁）	25.9(5.9)	25.5(6.4)	0.2	0.831
受教育年限	12.2(3.3)	12.0(2.6)	0.2	0.823
患病时间（月）	13.7(9.6)	-	-	-
治疗时间（d）	58.4(89.5)	-	-	-
氯丙嗪当量（mg）	588.4（293.7）	-	-	-
PANSS总分	58.9(8.8)	31.7(1.2)	13.0	<0.001
PANSS阳性症状	15.1(3.9)	7.0(0.0)	8.9	<0.001
PANSS阴性症状	12.2(3.4)	7.3(0.5)	6.2	<0.001
PANSS一般症状	31.6(5.3)	17.4(1.0)	11.1	<0.001
PSP总分	58.9(12.1)	89.1(2.4)	-10.4	<0.001

项目	记忆负荷	组别	准确率	反应时（s）
面孔工作记忆	低	SZ组	0.791±0.143	0.653±0.219
		对照组	0.904±0.057	0.384±0.194
	高	SZ组	0.645±0.071	0.714±0.219
		对照组	0.710±0.078	0.529±0.237
房子工作记忆	低	SZ组	0.814±0.138	0.683±0.221
		对照组	0.925±0.062	0.344±0.186
	高	SZ组	0.671±0.083	0.721±0.210
		对照组	0.766±0.088	0.483±0.205

指标		F值	P值
准确率	任务×负荷×组别	1.655	0.207
	任务×负荷	2.254	0.143
	负荷×组别	2.419	0.129
	任务×组别	0.689	0.412
	任务	13.769	0.001
	负荷	242.390	<0.001
	组别	11.696	0.002
反应时	任务×负荷×组别	0.356	0.555
	任务×负荷	1.202	0.281
	负荷×组别	8.798	0.005
	任务×组别	7.562	0.009
	任务	1.210	0.279
	负荷	37.907	<0.001
	组别	14.533	0.001

组别		记忆负荷	T值	P值
SZ组	正确率	低负荷	-1.281	0.218
		高负荷	-1.725	0.103
	反应时	低负荷	-1.543	0.141
		高负荷	-0.286	0.778
对照组	正确率	低负荷	-1.770	0.095
		高负荷	-4.138	0.001
	反应时	低负荷	2.938	0.009
		高负荷	3.460	0.003

项目		病程	药量^a)	PANSS阳性症状	PANSS阴性症状	PANSS一般症状	PANSS总分
面孔工作记忆	准确率（低）	-0.040	0.247	0.140	-0.183	0.291	-0.050
	准确率（高）	-0.264	-0.098	0.289	-0.264	0.188	0.030
	反应时（低）	0.387	0.031	0.218	-0.182	-0.020	-0.190
	反应时（高）	0.386	-0.034	0.328	-0.413	0.255	0.160
房子工作记忆	准确率（低）	-0.300	0.150	0.037	-0.191	0.043	0.139
	准确率（高）	-0.148	0.110	0.283	-0.201	0.241	0.104
	反应时（低）	0.322	0.005	0.288	-0.123	0.015	-0.310
	反应时（高）	0.449	-0.081	0.432	-0.330	0.282	-0.305

首发精神分裂症患者的视觉工作记忆缺陷相关研究

Study on visual working memory deficit in patients with first-episode schizophrenia

RichHTML

PDF (PC)

可视化

摘要/Abstract

引用本文

使用本文

图/表 7

参考文献 17

相关文章 1

编辑推荐

Metrics

本文评价