诊断学理论与实践

诊断学理论与实践 ›› 2019, Vol. 18 ›› Issue (06): 676-679.doi: 10.16150/j.1671-2870.2019.06.014

• 论著 • 上一篇    下一篇

HIV病毒过滤器过滤效率的评估实验研究

张林, 周莹, 李海聪, 孙美艳, 孙文秀, 陆玲庆, 朱召芹, 唐琪, 张仁芳, 沈银忠, 卢洪洲()   

  1. 上海市公共卫生临床中心感染与免疫科,上海 201508
  • 收稿日期:2019-10-10 出版日期:2019-12-25 发布日期:2019-12-25
  • 通讯作者: 卢洪洲 E-mail:luhongzhou@fudan.edu.cn

Experimental evaluation of efficacy of a HIV filter

ZHANG Lin, ZHOU Ying, LI Haicong, SUN Meiyan, SUN Wenxiu, LU Lingqing, ZHU Zhaoqin, TANG Qi, ZHANG Renfang, SHEN Yinzhong, LU Hongzhou()   

  1. Department of Infectious Immunity, Shanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China
  • Received:2019-10-10 Online:2019-12-25 Published:2019-12-25
  • Contact: LU Hongzhou E-mail:luhongzhou@fudan.edu.cn

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摘要：

目的：检验某公司生产的一次性人类免疫缺陷病毒（human immunodeficiency virus, HIV）过滤器的HIV去除率。方法：使用某公司生产的一次性HIV过滤器,将含有HIV的血浆通过该过滤器加压过滤,通过检测过滤前后血浆中的HIV RNA含量,判断该HIV病毒过滤器的滤过效率。结果：本研究共纳入10份血样,一次性HIV过滤器平均去除率为96.62%,过滤前后的血浆HIV含量差异有统计学意义（P=0.001）,过滤率高低与过滤前HIV含量高低间未发现线性关系（P=0.924 2）。结论：一次性HIV过滤器对HIV病毒的病毒去除率处于较高水平,结果提示采用物理吸附过滤HIV病毒的方法是较可行的。

关键词: 人类免疫缺陷病毒, 滤过膜, 去除率

Abstract:

Objective: To test the efficacy of a disposable membrane filter for the elimination of HIV. Methods: A total of 10 plasma samples were tested in this study. Plasma samples containing HIV were pressurizedly filtered through the filter. Copies of HIV RNA in the plasma before and after filtration were counted to calculate the efficacy of the filter. Results: The average HIV clearance rate of the filter was 96.62%. There was significant difference in number of HIV RNA copies before and after filtration (P=0.001). However, linear relationship was not seen between the clearance rate and the initial number of HIV RNA copies (P=0.924 2). Conclusions: The HIV clearance rate of this disposable membrane filter is high, and it might be feasible to eliminate the HIV virus by physical adsorption.

Key words: Human immunodeficiency virus, Filtration membrane, Clearance rate

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