肾上腺醛固酮和皮质醇共分泌瘤一例报告

doi:10.16150/j.1671-2870.2020.05.015

诊断学理论与实践 ›› 2020, Vol. 19 ›› Issue (05): 525-527.doi: 10.16150/j.1671-2870.2020.05.015

肾上腺醛固酮和皮质醇共分泌瘤一例报告

胡哲^1a, 陈歆^1a(), 罗芳秀^1b, 初少莉^1a, 王继光^1a^,²

1.上海交通大学医学院附属瑞金医院 a. 高血压科,b. 病理科,上海 200025
2.上海市高血压研究所,上海 200025

收稿日期:2020-07-27 出版日期:2020-10-25 发布日期:2022-07-14
通讯作者: 陈歆 E-mail:heartmedi@163.com
基金资助:
上海市嘉定区卫生和计划生育委员会高血压重点专科项目(JDYXZDZK-2);上海申康医院发展中心临床科技创新项目(SHDC12016232);上海交通大学医学院附属瑞金医院北院研究基金(2017ZY11)

Received:2020-07-27 Online:2020-10-25 Published:2022-07-14

摘要/Abstract

中图分类号:

R544.1

胡哲, 陈歆, 罗芳秀, 初少莉, 王继光. 肾上腺醛固酮和皮质醇共分泌瘤一例报告[J]. 诊断学理论与实践, 2020, 19(05): 525-527.

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参考文献 14

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[3]	Piaditis GP, Kaltsas GA, Androulakis Ⅱ, et al. High prevalence of autonomous cortisol and aldosterone secretion from adrenal adenomas[J]. Clin Endocrinol (Oxf), 2009, 71(6):772-778. doi: 10.1111/j.1365-2265.2009.03551.x URL
[4]	Bhatt PS, Sam AH, Meeran KM, et al. The relevance of cortisol co-secretion from aldosterone-producing adenomas[J]. Hormones (Athens), 2019, 18(3):307-313. doi: 10.1007/s42000-019-00114-8 URL
[5]	Akehi Y, Yanase T, Motonaga R, et al. High prevalence of diabetes in patients with primary aldosteronism (PA) associated with subclinical hypercortisolism and prediabetes more prevalent in bilateral than unilateral PA: a large, multicenter cohort study in japan[J]. Diabetes Care, 2019, 42(5):938-945. doi: 10.2337/dc18-1293 pmid: 31010944
[6]	Nakajima Y, Yamada M, Taguchi R, et al. Cardiovascular complications of patients with aldosteronism associated with autonomous cortisol secretion[J]. J Clin Endocrinol Metab, 2011, 96(8):2512-2518. doi: 10.1210/jc.2010-2743 pmid: 21593113
[7]	Späth M, Korovkin S, Antke C, et al. Aldosterone- and cortisol-co-secreting adrenal tumors: the lost subtype of primary aldosteronism[J]. Eur J Endocrinol, 2011, 164(4):447-455. doi: 10.1530/EJE-10-1070 URL
[8]	Yasuda S, Hikima Y, Kabeya Y, et al. Clinical characterization of patients with primary aldosteronism plus subclinical Cushing's syndrome[J]. BMC Endocr Disord, 2020, 20(1):9. doi: 10.1186/s12902-020-0490-0 URL
[9]	Fallo F, Bertello C, Tizzani D, et al. Concurrent primary aldosteronism and subclinical cortisol hypersecretion: a prospective study[J]. J Hypertens, 2011, 29(9):1773-1777. doi: 10.1097/HJH.0b013e32834937f3 URL
[10]	Goupil R, Wolley M, Ungerer J, et al. Use of plasma metanephrine to aid adrenal venous sampling in combined aldosterone and cortisol over-secretion[J]. Endocrinol Diabetes Metab Case Rep, 2015, 2015:150075.
[11]	Omura M, Saito J, Matsuzawa Y, et al. Supper-selective ACTH-stimulated adrenal vein sampling is necessary for detecting precisely functional state of various lesions in unilateral and bilateral adrenal disorders, inducing primary aldosteronism with subclinical Cushing's syndrome[J]. Endocr J, 2011, 58(10):919-920. doi: 10.1507/endocrj.EJ11-0210 URL
[12]	Makita K, Nishimoto K, Kiriyama-Kitamoto K, et al. A novel method: super-selective adrenal venous sampling[J]. J Vis Exp, 2017,(127):55716.
[13]	Funder JW, Carey RM, Mantero F, et al. The management of primary aldosteronism: case detection, diagnosis, and treatment: an Endocrine Society Clinical Practice Guideline[J]. J Clin Endocrinol Metab, 2016, 101(5):1889-1916. doi: 10.1210/jc.2015-4061 pmid: 26934393
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时间	血皮质醇 (μg/dL)	ACTH (pg/mL）	尿皮质醇（μg/24 h)
基础	11.57	4.77 ↓	533.3 ↑
用药后第1天	10.58	5.22 ↓	693.0 ↑
用药后第2天	11.16	6.24 ↓	624.0 ↑

指标	术前	术后1个月	术后3个月
血钾(mmol/L)	2.42	4.54	3.93
血醛固酮(pg/mL)	715.72	50.40	46.19
血浆肾素活性[ng/(mL·h)]	0.04	0.04	1.46
血皮质醇(μg/dL)	11.57	10.24	-
促肾上腺皮质激素(pg/mL）	4.77	41.31	-
尿皮质醇(μg/24 h)	533.25	-	-

肾上腺醛固酮和皮质醇共分泌瘤一例报告

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