Abstract: Objective: To analyze the etiology and characteristics of adverse reactions of blood transfusion, and to explore measures to reduce the adverse reactions. Methods: Data of adverse reactions of blood transfusion from 2011 to 2015 were retrospectively reviewed, and all the adverse reactions were statistically analyzed. Results: In the past five years, a total of 17 592 cases receiving blood transfusion and 58 cases suffered from adverse transfusion reactions, with an incidence of 0.33%. Most of them were caused by following blood products: single donor platelets (with an incidence of 1.02%); plasma products (with an incidence of 0.49%); suspended red blood cells (with an incidence of 0.18%). The incidences of adverse blood transfusion reactions caused by different blood components were significantly different ( χ²=26.1,P<0.01). Most of the adverse reactions of blood transfusion were anaphylactic reactions, and were mainly caused by blood plasma transfusion and single donor platelets transfusion,with a constituent ratio of 63.8%; constituent ratio of febrile reaction was 36.2%, commonly caused by transfusing suspended red blood cells. The overall incidence of blood transfusion reactions decreased year by year. Conclusions: For reducing the incidence of transfusion reaction and ensuring the safety of blood transfusion, the management of blood transfusion should be strengthened and the indications of blood transfusion should be held strictly, and reducing unnecessary blood transfusions, especially avoiding the transfusing of plasma with matched red blood cells.

Key words: Adverse reactions of blood transfusion, Febrile reaction, Anaphylactic reaction, Blood transfusion indications