Abstract: Objective: To investigate the distribution and drug sensitivity of pathogens of fungal vaginitis in Jiading District of Shanghai for providing a guidance for clinical diagnosis and treatment of the disease. Methods: Altogether 1 097 leucorrhea specimens were collected from patients with fungal vaginitis in obstetrics and gynecology department from 5 hospitals(Jiading District Central Hospital, Maternal and Child Health Hospital, Jiading District Hospital of Traditional Chinese Medicine, Nanxiang Hospital and Anting Hospital), from July 2015 to June 2016. The specimens were cultured and drug sensitivity test was performed. The results were analyzed by SPSS 13.0. Results: There was no significant difference in distribution of pathogens among these hospitals, and Candida albicans was the most common (81.5%). The highest proportion (14.6 percent) of non-Candidaalbicans was found in Candidaglabrata. The proportion of Candida albicans in recurrent patients was 67.0%. Overall sensitive rates of all strains to fluconazole, voriconazole and itraconazole were 98.9%, 92.0% and 70.0%, respectively. The sensitivity of Candida albicans and non-Candida albicans to 3 azoles were 99.6%, 92.6%, 72.4% and 84.8%, 89.2% and 59.1%, respectively. For hospital, the five hospitals showed significant differences in sensitivity of drugs in the case of voriconazole and itraconazole. Conclusions: Candida albicans is the main pathogen of fungal vaginitis in Jiading District of Shanghai. The distribution of pathogens in patients with recurrent fungal vaginitis shows a trend of diversity. Some pathogens appeare with more obvious itraconazole resistance. There are also differences in drug sensitivity among the strains and different hospitals. To emphasize the pathogen examination and drug sensitivity test of fungal vaginitis is helpful for clinicians to prescribe better clinical treatment.

Key words: Fungal vaginitis, Candida, Drug sensitivity test