Abstract: Objective: To evaluate the associated factors for within-day and day-to-day glycemic variability (GV) in type 2 diabetes(T2D) patients. Methods: A total of 183 hospitalized patients with T2D receiving insulin therapy were enrolled. Continuous glucose monitoring (CGM) was performed in all the subjects. The within-day GV was evaluated by using mean amplitude of glycemic excursion(MAGE), and day-to-day GV by absolute means of daily differences (MODD). Genera-lized linear model was used to estimate associated factors for within-day and day-to-day glycemic variability. Results: CGM revealed that mean MAGE and MODD were（4.75±0.91） mmol/L and （2.62±0.76） mmol/L, respectively. For within-day glycemic variability, family history of diabetes, lower levels of C-peptide, uric acid, HDL-C were independent related factors for increase of MAGE. For day-to-day glycemic variability, duration of diabetes, glycosylated hemoglobin, aspartate aminotransferase(AST) and high density lipoprotein cholesterol （HDL-C） were positively correlated with MODD, while C-peptide and premixed insulin injection were negatively correlated with MODD. Conclusions: Family history of diabetes, duration of diabetes, HbA1c, AST, HDL-C, serum levels of C-peptide, premixed insulin injection, history of CVD and serum concentration of uric acid are significantly associated with GV parameters, which indicates that the function of pancreatic beta cells and insulin sensitivity may influence the glycemic variability in type 2 diabetes patients. Premixed insulin injection may exert a better curative effect on blood glucose control in Chinese type 2 diabetes patients.

Key words: Type 2 diabetes, Glycemic variability, Mean amplitude of glycemic excursion, Absolute means of daily glycemic differences