Comparison of diagnostic value of new infection biomarker presepsin with procalcitonin, C-reactive protein and interleukin-6 in diagnosis of bacterial infection

doi:10.16150/j.1671-2870.2018.05.019

Abstract

Abstract: Objective: To explore the diagnostic value of a new infection biomarker presepsin (soluble CD14 molecular subtype) in bacterial infection, and compared with procalcitonin (PCT), C-reactive protein (CRP) and interleukin-6 (IL-6) for the diagnosis of bacterial infection. Methods: Patients with positive blood culture admitted between December 2016 and May 2017 were enrolled, and 57 cases of normal healthy subjects at the same period were served as controls.The levels of serum presepin, procalcitonin, CRP and IL-6 were determined. Using ROC curve and survival analysis to evaluate the value of different biomarkers for the diagnosis of bacterial infection, and to explore whether there were differences between different age groups. Results: The level of serum presepsin was significantly high in bacterial infection group than in non-infectioncontrol group （P<0.05）. In the infection group, there was no significant difference in serum presepsin le-vel between patients of different age groups (P>0.05). Compared with other diagnostic biomarkers through ROC curve analysis, the area under curve（AUC） of presepsin was 0.854, higher than 0.802 of PCT and 0.772 of CRP and 0.693 of IL-6, respectively. AUC of serum PCT level for differentiating gram-negative from gram-positive bacterial infection was 0.944, higher than those of presepsin and IL-6. Conclusion: The infection biomarkers presepsin has high sensitivity and specificity for the diagnosis of bacterial infection, and it can be applied in patients of different age group and in differentiating gram-negative from gram-positive bacterial infection.

Key words: Bacterial infection, Presepsin, Biomarkers, Procalcitonin (PCT), IL-6, CRP

CLC Number:

R446

DU Kun, YANG Xi, BIAN Binxian, REN Yiqian, ZHANG Guanghui. Comparison of diagnostic value of new infection biomarker presepsin with procalcitonin, C-reactive protein and interleukin-6 in diagnosis of bacterial infection[J]. Journal of Diagnostics Concepts & Practice, 2018, 17(05): 581-585.

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