Journal of Diagnostics Concepts & Practice ›› 2025, Vol. 24 ›› Issue (01): 89-94.doi: 10.16150/j.1671-2870.2025.01.013
• Review • Previous Articles Next Articles
Received:
2024-01-31
Accepted:
2024-08-05
Online:
2025-02-25
Published:
2025-02-25
Contact:
SHEN Xi
E-mail:carl_shen2005@126.com
CLC Number:
PENG Hanwei, SHEN Xi. Clinical research progress on retinal changes in Alzheimer’s disease[J]. Journal of Diagnostics Concepts & Practice, 2025, 24(01): 89-94.
[1] |
HOU Y, DAN X, BABBAR M,et al. Ageing as a risk factor for neurodegenerative disease[J]. Nat Rev Neurol, 2019, 15(10):565-581.
doi: 10.1038/s41582-019-0244-7 pmid: 31501588 |
[2] |
HAYREH S S. The 1994 Von Sallman Lecture. The optic nerve head circulation in health and disease[J]. Exp Eye Res, 1995, 61(3):259-272.
doi: 10.1016/s0014-4835(05)80121-6 pmid: 7556490 |
[3] |
HAYREH S S. The blood supply of the optic nerve head and the evaluation of it - myth and reality[J]. Prog Retin Eye Res, 2001, 20(5):563-593.
doi: 10.1016/s1350-9462(01)00004-0 pmid: 11470451 |
[4] |
JIA Y, TAN O, TOKAYER J,et al. Split-spectrum amplitude-decorrelation angiography with optical coherence tomography[J]. Opt Express, 2012, 20(4):4710-4725.
doi: 10.1364/OE.20.004710 pmid: 22418228 |
[5] |
SPAIDE R F, FUJIMOTO J G, WAHEED N K,et al. Optical coherence tomography angiography[J]. Prog Retin Eye Res, 2018, 64:1-55.
doi: S1350-9462(17)30056-3 pmid: 29229445 |
[6] |
KASHANI A H, CHEN C L, GAHM J K,et al. Optical coherence tomography angiography: A comprehensive review of current methods and clinical applications[J]. Prog Retin Eye Res, 2017, 60:66-100.
doi: S1350-9462(16)30092-1 pmid: 28760677 |
[7] | SAVASTANO M C, LUMBROSO B, RISPOLI M. In vivo characterization of retinal vascul-arization morphology usi-ng optical cohe-rence tomography angiography[J]. Retina, 2015, 35(11):2196-2203. |
[8] |
JIANG H, DEBUC D C, RUNDEK T,et al. Automated segmentation and fractal analysis of high-resolution non-invasive capillary perfusion maps of the human retina[J]. Microvasc Res, 2013, 89:172-175.
doi: 10.1016/j.mvr.2013.06.008 pmid: 23806780 |
[9] | CHEN Q, MA Q, WU C,et al. Macular vascular fractal dimension in the deep capillary layer as an early indicator of microvascular loss for retinopathy in type 2 diabetic patients[J]. Invest Ophthalmol Vis Sci, 2017, 58(9):3785-3794. |
[10] | SHI C, CHEN Y, KWAPONG W R,et al. Charact-erization by fractal dimension analysis of the retinal capillary network in parkinson disease[J]. Retina, 2020, 40(8):1483-1491. |
[11] | WU S Z, MASURKAR A V, BALCER L I. Afferent and efferentvisual markers of Alzheimer's disease: a review and update in early stage disease[J]. Front Aging Neurosci, 2020, 12:572337. |
[12] |
GAUTHIER S, REISBERG B, ZAUDIG M,et al. Mild cognitive impairment[J]. Lancet, 2006, 367(9518):1262-1270.
doi: 10.1016/S0140-6736(06)68542-5 pmid: 16631882 |
[13] | SPERLING R A, AISEN P S, BECKETT L A,et al. Toward defi-ning the preclinical stages of Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelinesfor Alzheimer's disease[J]. Alzheimers Dement, 2011, 7(3):280-292. |
[14] | JOHNSON K A, FOX N C, SPERLING R A,et al. Brain imaging in Alzheimer disease[J]. Cold Spring Harb Perspect Med, 2012, 2(4):a006213. |
[15] | THAL L J, KANTARCI K, REIMAN E M,et al. The role of biomarkers in clinical trials for Alzheimer disease[J]. Alzheimer Dis Assoc Disord, 2006, 20(1):6-15. |
[16] | HOLTZMAN D M, MORRIS J C, GOATE A M. Alzheimer's disease: the challenge of the second century[J]. Sci TranslMed, 2011, 3(77):77sr1. |
[17] | LANE C A, HARDY J, SCHOTT J M. Alzheimer's di-sease[J]. Eur J Neurol, 2018, 25(1):59-70. |
[18] |
THOMSON K L, YEO J M, WADDELL B,et al. A systematic review and meta-analysis of retinal nerve fiber layer change in dementia, using optical coherence tomography[J]. Alzheimers Dement (Amst), 2015, 1(2):136-143.
doi: 10.1016/j.dadm.2015.03.001 pmid: 27239501 |
[19] | KIRBAS S, TURKYILMAZ K, ANLAR O,et al. Retinal nerve fiber layer thickness in patients with Alzheimer di-sease[J]. J Neuroophthalmol, 2013, 33(1):58-61. |
[20] | LU Y, LI Z, ZHANG X,et al. Retinal nerve fiber layer structure abnormalities in early Alzheimer’s disease: evidence in optical coherence tomography[J]. Neurosci Lett, 2010, 480(1):69-72. |
[21] | KESLER A, VAKHAPOVA V, KORCZYN A D,et al. Retinal thickness in patients with mild cognitive impairment and Alzheimer’s disease[J]. Clin Neurol Neurosurg, 2011, 113(7):523-526. |
[22] | KROMER R, SERBECIC N, HAUSNER L,et al. Detection of retinal nerve fiber layer defects in Alzheimer’s disease using SD-OCT[J]. Front Psychiatry, 2014, 5:22. |
[23] | ISERI P K, ALTINAŞ O, TOKAY T,et al. Relationship between cognitive impairment and retinal morphological and visual functional abnormalities in Alzheimer disease[J]. J Neuroophthalmol, 2006, 26(1):18-24. |
[24] | BERISHA F, FEKE G T, TREMPE C L,et al. Retinal abnormalities in early Alzheimer’s disease[J]. Invest Ophthalmol Vis Sci, 2007, 48(5):2285-2289. |
[25] | LARROSA J M, GARCIA-MARTIN E, BAMBO M P,et al. Potential new diagnostic tool for Alzheimer’s disease using a linear discriminant function for Fourier domain optical coherence tomography[J]. Invest Ophthalmol Vis Sci, 2014, 55(5):3043-3051. |
[26] | POLO V, RODRIGO M J, GARCIA-MARTIN E,et al. Visual dysfunction and its correlation with retinal changes in patients with Alzheimer’s disease[J]. Eye (Lond), 2017, 31(7):1034-1041. |
[27] | CUNHA J P, PROENÇA R, DIAS-SANTOS A,et al. OCT in Alzheimer’s disease: thinning of the RNFL and superior hemiretina[J]. Graefes Arch Clin Exp Ophthalmol, 2017, 255(9):1827-1835. |
[28] | GAO L, LIU Y, LI X,et al. Abnormal retinal nerve fiber layer thickness and macula lutea in patients with mild cognitive impairment and Alzheimer’s disease[J]. Arch Gerontol Geriatr, 2015, 60(1):162-167. |
[29] | COPPOLA G, DI RENZO A, ZICCARDI L,et al. Optical coherence tomography in Alzheimer’s disease: a meta-analysis[J]. PLoS One, 2015, 10(8):e0134750. |
[30] | HE X F, LIU Y T, PENG C,et al. Optical coherence tomography assessed retinal nerve fiber layer thickness in patients with Alzheimer’s disease: a meta-analysis[J]. Int J Ophthalmol, 2012, 5(3):401-405. |
[31] | GARCIA-MARTIN E, BAMBO M P, MARQUES M L,et al. Ganglion cell layer measurements correlate with di-sease severity in patients with Alzheimer’s disease[J]. Acta Ophthalmol, 2016, 94(6):e454-459. |
[32] | LIU D, ZHANG L, LI Z,et al. Thinner changes of the retinal nerve fiber layer in patients with mild cognitive impairment and Alzheimer’s disease[J]. BMC Neurol, 2015, 15:14. |
[33] | SANTOS C Y, JOHNSON L N, SINOFF S E,et al. Change in retinal structural anatomy during the preclinical stage of Alzheimer’s disease[J]. Alzheimers Dement (Amst), 2018, 10:196-209. |
[34] |
OKTEM E O, DERLE E, KIBAROGLU S,et al. The relationship between the degree of cognitive impairment and retinal nerve fiber layer thickness[J]. Neurol Sci, 2015, 36(7):1141-1146.
doi: 10.1007/s10072-014-2055-3 pmid: 25575807 |
[35] | CHEUNG CY, ONG Y T, HILAL S,et al. Retinal ganglion cell analysis using high-definition optical cohe-rence tomography in patients with mild cognitive impairment and Alzheimer’s disease[J]. J Alzheimers Dis, 2015, 45(1):45-56. |
[36] | WARD D D, MAUSCHITZ M M, BÖNNIGER M M,et al. Association of retinal layer measurements and adult cognitive function: A population-based study[J]. Neurology, 2020, 95(9):e1144-e1152. |
[37] | FERRARI L, HUANG S C, MAGNANI G,et al. Optical coherence tomography reveals retinal neuroaxonal thinning in frontotemporal dementia as in Alzheimer’s disea-se[J]. J Alzheimers Dis, 2017, 56(3):1101-1107. |
[38] | PAQUET C, BOISSONNOT M, ROGER F,et al. Abnormal retinal thickness in patients with mild cognitive impairment and Alzheimer’s disease[J]. Neurosci Lett, 2007, 420(2):97-99. |
[39] | ASCASO F J, CRUZ N, MODREGO P J,et al. Retinal alterations in mild cognitive impairment and Alzheimer’s disease: an optical coherence tomography study[J]. J Neurol, 2014, 261(8):1522-1530. |
[40] | SNYDER P J, JOHNSON L N, LIM Y Y,et al. Nonvascular retinal imaging markers of preclinical Alzheimer’s disease[J]. Alzheimers Dement (Amst), 2016, 4:169-178. |
[41] |
ITO Y, SASAKI M, TAKAHASHI H,et al. Quantitative assessment of the retina using OCT and associations with cognitive function[J]. Ophthalmology, 2020, 127(1):107-118.
doi: S0161-6420(18)33382-7 pmid: 31307828 |
[42] | SHAO Y, JIANG H, WEI Y,et al. Visualization of focal thinning of the ganglion cell-inner plexiform layer in patients with mild cognitive impairment and Alzheimer’s disease[J]. J Alzheimers Dis, 2018, 64(4):1261-1273. |
[43] |
WU Y, WANG X N, WANG N,et al. Regularity changes of the retinal nerve fiber layer and macular ganglion cell complex in patients with the amnestic mild cognitive impairment[J]. Int J Neurosci, 2018, 128(9):849-853.
doi: 10.1080/00207454.2018.1438428 pmid: 29447481 |
[44] | VAN DE KREEKE J A, NGUYEN H T, DEN HAAN J,et al. Retinal layer thickness in preclinical Alzheimer’s disease[J]. Acta Ophthalmol, 2019, 97(8):798-804. |
[45] | PATTON N, ASLAM T, MACGILLIVRAY T,et al. Retinal vascular image analysis as a potential screening tool for cerebrovascular disease: a rationale based on homolo-gy between cerebral and retinal microvasculatures[J]. J Anat, 2005, 206(4):319-348. |
[46] | YEH T C, KUO C T, CHOU Y B. Retinal microvascular changes in mild cognitive impairment and Alzheimer’s disease: a systematic review, meta-analysis, and meta-regression[J]. Front Aging Neurosci, 2022, 14:860759. |
[47] | BULUT M, KURTULUŞ F, GÖZKAYA O,et al. Evaluation of optical coherence tomography angiographic fin-dings in Alzheimer’s type dementia[J]. Br J Ophthalmol, 2018, 102(2):233-237. |
[48] | LAHME L, ESSER E L, MIHAILOVIC N,et al. Evaluation of ocular perfusion in Alzheimer’s disease using optical coherence tomography angiography[J]. J Alzheimers Dis, 2018, 66(4):1745-1752. |
[49] | JIANG H, WEI Y, SHI Y,et al. Altered Macular Microvasculature in Mild Cognitive Impairment and Alzheimer Disease[J]. J Neuroophthalmol, 2018, 38(3):292-298. |
[50] | YOON S P, GREWAL D S, THOMPSON A C,et al. Retinal microvascular and neurodegenerative changes in Alzheimer’s disease and mild cognitive impairment compared with control participants[J]. Ophthalmol Retina, 2019, 3(6):489-499. |
[51] | WU J, ZHANG X, AZHATI G,et al. Retinal microvascular attenuation in mental cognitive impairment and Alzheimer’s disease by optical coherence tomography angio-graphy[J]. Acta Ophthalmol, 2020, 98(6):e781-e787. |
[52] | ZHANG Y S, ZHOU N, KNOLL B M,et al. Parafoveal vessel loss and correlation between peripapillary vessel density and cognitive performance in amnestic mild cognitive impairment and early Alzheimer’s Disease on optical coherence tomography angiography[J]. PLoS One, 2019, 14(4):e0214685. |
[53] |
O'BRYHIM B E, APTE R S, KUNG N,et al. Association of preclinical alzheimer disease with optical coherence tomographic angiography findings[J]. JAMA Ophthalmol, 2018, 136(11):1242-1248.
doi: 10.1001/jamaophthalmol.2018.3556 pmid: 30352114 |
[54] | VAN DE KREEKE J A, NGUYEN H T, KONIJNENBERG E,et al. Optical coherence tomography angiography in preclinical Alzheimer’s disease[J]. Br J Ophthalmol, 2020, 104(2):157-161. |
[55] | LIM J K H, LI Q X, HE Z,et al. The eye as a biomarker for Alzheimer’s disease[J]. Front Neurosci, 2016, 10:536. |
[56] | PARISI V, RESTUCCIA R, FATTAPPOSTA F,et al. Morphological and functional retinal impairment in Alzheimer’s disease patients[J]. Clin Neurophysiol, 2001, 112(10):1860-1867. |
[57] | MAHAJAN D, VOTRUBA M. Can the retina be used to diagnose and plot the progression of Alzheimer’s disease? [J] Acta Ophthalmol, 2017, 95(8):768-777. |
[58] | KRASODOMSKA K, LUBIŃSKI W, POTEMKOWSKI A,et al. Pattern electroretinogram (PERG) and pattern visual evoked potential (PVEP) in the early stages of Alzheimer’s disease[J]. Doc Ophthalmol, 2010, 121(2):111-121. |
[59] | KATZ B, RIMMER S, IRAGUI V,et al. Abnormal pattern electroretinogram in Alzheimer’s disease: evidence for retinal ganglion cell degeneration? [J]. Ann Neurol, 1989, 26(2):221-225. |
[60] | BINETTI G, CAPPA S F, MAGNI E,et al. Disorders of visual and spatial perception in the early stage of Alzheimer’s disease[J]. Ann N Y Acad Sci, 1996, 777:221-225. |
[61] |
JUSTINO L, KERGOAT M, BERGMAN H,et al. Neuroretinal function is normal in early dementia of the Alzheimer type[J]. Neurobiol Aging, 2001, 22(4):691-695.
pmid: 11445270 |
[62] | BATEMAN R. Alzheimer’s disease and other dementias: advances in 2014[J]. Lancet Neurol, 2015, 14(1):4-6. |
[63] | NGOO Q Z, WAN HITAM W H, AB RAZAK A. Evaluation of retinal nerve fiber layer thickness, electroretinogram and visual evoked potential in patients with Alzheimer's disease[J]. J Ophthalmol, 2019, 2019:6248185. |
[64] | FIX S T, ARRUDA J E, ANDRASIK F,et al. Using visual evoked potentials for the early detection of amnestic mild cognitive impairment: a pilot investigation[J]. Int J Geriatr Psychiatry, 2015, 30(1):72-79. |
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