Clinical electromyography study of patients with restless legs syndrome in Chinese population

doi:10.16150/j.1671-2870.2019.05.015

Abstract

Abstract:

Objectives: To evaluate sleep, mood and autonomic function objectively and electrophysiology subjectively in Chinese RLS (Restless legs syndrome, RLS) patients. Methods: A total of 15 RLS patients and 16 non-RLS controls were recruited from out-patient clinics of neurology department. Questionnaires（PSQI、ESS、HAMA、HAMD、COMPASS-31、SCOPA-AUT） were asked and electromyography （SSR、F-wave、H reflex） was conducted. Results: PSQI score was higher in RLS patients than controls. Mood and autonomic score didn't differ between two groups. In addition, F-wave latency, H-reflex latency, H/M amplitude ratio and SSR latency was similar between two groups. H-reflex amplitude and SSR amplitude didn't differ, neither. SSR amplitude (P=0.042) and H-reflex amplitude (P=0.047) was statically significant, but probably false positive. Conclusion: RLS symptom impacts sleep, especially during bedtime over mood and autonomic function. In the meantime, there is still a lack of electromyography biomarker to help diagnose RLS. More studies with bigger sample size are needed in the future. It is possible that small fiber dysfunction is not involved in the pathophysiology of RLS.

Key words: Restless legs syndrome, Scale, Electromyography

CLC Number:

R741

LU Yanqing, CHEN Jie, MA Jianfang, WAN Yanping. Clinical electromyography study of patients with restless legs syndrome in Chinese population[J]. Journal of Diagnostics Concepts & Practice, 2019, 18(05): 565-569.

Figures/Tables 4

References 18

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项目	RLS组(n=15)	对照组(n=16)	P值
性别,女性[n(%)]	9 (60.00)	9 (56.25)	0.833
年龄 (岁)	66.86±15.47	59.00±14.79	0.166

量表	RLS组(n=15)	对照组(n=16)	P值
PSQI评分	9.36±5.68	3.87±3.02	0.012
ESS评分	1.00±1.26	2.40±2.13	0.074
HAMA评分	6.80±7.04	3.07±4.03	0.163
HAMD评分	3.60±4.43	2.13±2.95	0.517
COMPASS-31评分	12.87±15.39	13.22±12.03	0.823
SCOPA-AUT评分	6.80±3.01	4.87±4.26	0.094

电生理参数		RLS组	对照组	P值
腓浅神经 (m/s)	右下肢	50.34±3.78	48.94±2.93	0.278
	左下肢	50.50±3.30	48.53±3.12	0.128
腓总神经 (m/s)	右下肢	48.24±4.49	48.48±3.47	0.877
	左下肢	49.12±3.50	48.40±2.99	0.572
胫神经 (m/s)	右下肢	46.36±3.66	47.68±3.58	0.357
	左下肢	46.73±3.73	47.88±3.44	0.404

电生理参数	肢侧	RLS组	对照组	P值
F-M均数 (ms)	右下肢	42.49±3.86	42.25±3.59	0.863
	左下肢	42.90±4.44	42.39±3.69	0.736
SSR起始潜伏期 (ms)	右下肢	2.16±0.38	1.98±0.29	0.181
	左下肢	2.06±0.36	1.99±0.30	0.573
SSR波幅 (μv)	右下肢	525.59±469.26	1187.7±983.32	0.042
	左下肢	529.87±464.52	953.89±683.38	0.144
H反射潜伏期(ms)	右下肢	30.09±3.14	29.57±1.75	0.627
	左下肢	30.55±3.51	30.02±2.58	0.687
H反射波幅 (μv)	右下肢	0.87±0.71	2.01±1.21	0.047
	左下肢	0.60±0.76	1.05±0.63	0.067
H/M 波幅比（%）	右下肢	10.74%±8.19%	27.8%±25.17%	0.076
	左下肢	13.38%±16.15%	25.6%±36.07%	0.296