Objective: To investigate the correlation between G protein-coupled receptor kinase-5 (GRK5) level in peripheral lymphocytes and the degree of cognitive impairment in Alzheimer's disease(AD) patients. Methods: A total of 64 patients with AD during January 2015 to December 2017 were enrolled and divided into two groups, including 27 cases of mild dementia and 37 cases of moderate-to-severe dementia; 30 healthy subjects were served as controls. Enzyme-linked immunosorbent assay(ELISA) was used to detect the GRK5 level in peripheral lymphocytes of AD patients and controls. Results: The GRK5 level in mild and moderate-to-severe AD patients was significantly lower than that in controls (P<0.001). Moreover, the GRK5 level in moderate-to-severe AD patients was significantly lower than that in the mild AD patients (P<0.001). Linear regression analyses revealed a strong positive correlation between the GRK5 level and the Mini Mental State Examination (MMSE) score (P<0.001). Conclusions: Our data suggestes that low level of GRK5 is existed in AD patients and mirrored the impairment of cognitive state. GRK5 level of peripheral blood lymphocytes might be used as a novel biomarker for the early diagnosis of AD patients.
SUN Jialan, HUANG Shu, LAI Xiaoyin, ZHU Wei, HU Rongguo, LI Longxuan
. Correlation between lymphocyte G-protein-coupled receptor kinase-5 level and cognitive impairment in patients with Alzheimer′s disease[J]. Journal of Diagnostics Concepts & Practice, 2018
, 17(04)
: 419
-422
.
DOI: 10.16150/j.1671-2870.2018.04.012
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