Journal of Diagnostics Concepts & Practice >

2019 , Vol. 18 >Issue 05: 565 - 569

DOI: https://doi.org/10.16150/j.1671-2870.2019.05.015

Original articles

Clinical electromyography study of patients with restless legs syndrome in Chinese population

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  • 1. Malu Community Health Service Center of Jiading District, Shanghai 201801, China
    2. Department of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China

Received date: 2018-07-31

  Online published: 2019-10-25

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Abstract

Objectives: To evaluate sleep, mood and autonomic function objectively and electrophysiology subjectively in Chinese RLS (Restless legs syndrome, RLS) patients. Methods: A total of 15 RLS patients and 16 non-RLS controls were recruited from out-patient clinics of neurology department. Questionnaires（PSQI、ESS、HAMA、HAMD、COMPASS-31、SCOPA-AUT） were asked and electromyography （SSR、F-wave、H reflex） was conducted. Results: PSQI score was higher in RLS patients than controls. Mood and autonomic score didn't differ between two groups. In addition, F-wave latency, H-reflex latency, H/M amplitude ratio and SSR latency was similar between two groups. H-reflex amplitude and SSR amplitude didn't differ, neither. SSR amplitude (P=0.042) and H-reflex amplitude (P=0.047) was statically significant, but probably false positive. Conclusion: RLS symptom impacts sleep, especially during bedtime over mood and autonomic function. In the meantime, there is still a lack of electromyography biomarker to help diagnose RLS. More studies with bigger sample size are needed in the future. It is possible that small fiber dysfunction is not involved in the pathophysiology of RLS.

Key words： Restless legs syndrome; Scale; Electromyography

Cite this article

LU Yanqing, CHEN Jie, MA Jianfang, WAN Yanping . Clinical electromyography study of patients with restless legs syndrome in Chinese population[J]. Journal of Diagnostics Concepts & Practice, 2019 , 18(05) : 565 -569 . DOI: 10.16150/j.1671-2870.2019.05.015

References

[1] Allen RP, Picchietti D, Hening WA, et al. Restless legs syndrome: diagnostic criteria, special considerations, and epidemiology. A report from the restless legs syndrome diagnosis and epidemiology workshop at the National Institutes of Health[J]. Sleep Med, 2003, 4(2):101-119.
[2] Ma JF, Xin XY, Liang L, et al. Restless legs syndrome in Chinese elderly people of an urban suburb in Shanghai: a community-based survey[J]. Parkinsonism Relat Disord, 2012, 18(3):294-298.
[3] García-Borreguero D, Williams AM. Dopaminergic augmentation of restless legs syndrome[J]. Sleep Med Rev, 2010, 14(5):339-346.
[4] Shneyder N, Adler CH, Hentz JG, et al. Autonomic complaints in patients with restless legs syndrome[J]. Sleep Med, 2013, 14(12):1413-1416.
[5] Kurt O, Yazici CM, Alp R, et al. Is it only a sleeping disorder or more? Restless legs syndrome and erectile function[J]. Scand J Urol, 2016, 50(5):392-395.
[6] Guggisberg AG, Hess CW, Mathis J. The significance of the sympathetic nervous system in the pathophysiology of periodic leg movements in sleep[J]. Sleep, 2007, 30(6):755-766.
[7] Han JK, Oh K, Kim BJ, et al. Cutaneous silent period in patients with restless leg syndrome[J]. Clin Neurophysiol, 2007, 118(8):1705-1710.
[8] Isak B, Uluc K, Salcini C, et al. A neurophysiological approach to the complex organisation of the spine: F-wave duration and the cutaneous silent period in restless legs syndrome[J]. Clin Neurophysiol, 2011, 122(2):383-390.
[9] Congiu P, Fantini ML, Milioli G, et al. F-Wave Duration as a Specific and Sensitive Tool for the Diagnosis of Restless Legs Syndrome/Willis-Ekbom Disease[J]. J Clin Sleep Med, 2017, 13(3):369-375.
[10] Shukla G, Goyal V, Srivastava A, et al. Quantitative thermal sensory testing and sympathetic skin response in primary Restless legs syndrome - A prospective study on 57 Indian patients[J]. Ann Indian Acad Neurol, 2012, 15(4):260-262.
[11] Isak B, Agan K, Ergun A, et al. Where is the core of the volcano? The undetermined origin of primary restless legs syndrome[J]. Int J Neurosci, 2011, 121(3):130-136.
[12] Rijsman RM, Stam CJ, de Weerd AW. Abnormal H-reflexes in periodic limb movement disorder; impact on understanding the pathophysiology of the disorder[J]. Clin Neurophysiol, 2005, 116(1):204-210.
[13] Buysse DJ, Reynolds CF 3rd, Monk TH, et al. The Pittsburgh Sleep Quality Index: a new instrument for psychia-tric practice and research[J]. Psychiatry Res, 1989, 28(2):193-213.
[14] Johns MW. A new method for measuring daytime sleepiness: the Epworth sleepiness scale[J]. Sleep, 1991, 14(6):540-545.
[15] 汪向东, 王希林, 马弘. 汉密尔顿焦虑量表[J]. 中国心理卫生杂志, 1999, 12:253-256.
[16] Walters AS, LeBrocq C, Dhar A, et al. Validation of the International Restless Legs Syndrome Study Group rating scale for restless legs syndrome[J]. Sleep Med, 2003, 4(2):121-132.
[17] Kohnen R, Martinez-Martin P, Benes H, et al. Rating of daytime and nighttime symptoms in RLS: validation of the RLS-6 scale of restless legs syndrome/Willis-Ekbom disease[J]. Sleep Med, 2016, 20:116-122.
[18] 张晶, 陈捷, 马建芳, 等. 剑桥-霍普金斯不宁腿量表诊断中国人群不宁腿综合征的临床研究[J]. 诊断学理论与实践, 2018, 17(2):165-169.
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