Objective: To implement a cloud-based solution for hypertension management in an outpatient setting and to assess the efficacy of cloud-based solution on control of blood pressure (BP). Methods: A cloud-based solution was developed, consisting of a Bluetooth-enabled BP monitor, a physician-end App, a cloud engine with knowledge database offering personalized lifestyle management and medication adherence contents. During Jan 1st 2018 and Dec 31st 2018, a total of 7 933 hypertensive patients were recruited into this study at Ruijin Hospital, Shanghai Jiao Tong University School of Medicine. The patients were divided into six different groups according to the intervention duration (2 months, 3 months, 4 months, 5 months, 6 months and more than 6 months). Changes in SBP, DBP, and final BP measurement distribution and hypertension staging as well as the time-effectiveness of the solution were studied. Results: The study population showed an average reduction in SBP by 8.88 mmHg (95%CI: 8.79-8.98, P<0.001), and DBP by 5.25 mmHg (95%CI: 5.23-5.27, P<0.001), respectively, in the before-after analysis. Hypertension staging distribution in the patients was improved, and the distribution at baseline vs last follow-up were normal BP, 0% vs 39%; stage-1, 69% vs 39%; stage-2, 23% vs 17%; and stage-3, 8% vs 5% (P<0.001). Further study revealed that BP reduction occurred after the first intervention and the reduction remained stably over time. Conclusions: The cloud-based solution might serve as an important tool for assisting BP management in outpatient clinic.