Objective: To investigate the impact of percutaneous coronary intervention (PCI) on quality of life (QOL) in patients with coronary heart disease (CHD). Methods: A total of 99 patients with CHD treated with PCI from April to December 2018 were enrolled. The Seattle Angina Questionnaire (SAQ) and the Patient Health Questionnaire-9 (PHQ-9) were performed to evaluate the quality of life (QOL) at 1 month and 6 months after PCI. QOL was assessed in respect to number of stents implanted (≤2 and >2), times of PCI (1 or >1) and SYNTAX score (light, medium and severe) using multi-factors and multi-levels of repeated measurements. Results: Both scores of SAQ and PHQ-9 were significantly improved at 6 months than those at 1 month after PCI. SAQ score was significantly lower at 1 month than that at 6 months (320.1±80.7 vs. 380.3 ±46.8, P<0.01), while PHQ-9 score was significantly higher at 1 month than that at 6 months (6.7±5.3 vs. 5.3±4.2, P<0.01). Furthermore, the interactive effects of number of stents implanted, times of PCI and SYNTAX score on the SAQ and PHA-9 scores were analyzed. The results showed that score of SAQ was not affected by the number of stents implanted, times of PCI and SYNTAX score 6 months after discharged from hospital. However, PHQ-9 score was affected by number of stents implanted and times of PCI. In patients with more than 2 stents implanted or multiple times of PCI, depression was not improved significantly at 6 months. Conclusions: The QOL is significantly improved at 6 months in patients treated with PCI. The improvement of SAQ score is not affected by number of stents implanted, times of PCI and SYNTAX score, while PHQ-9 is affected by number of stents implanted and times of PCI. In patients with multiple stents implanted or multiple times of PCI, the depression mood is not differed significantly between 1 month and 6 months after PCI.