Original articles

Correlation of blood pressure level with development and progression of chronic kidney disease in Chinese community diabetes patients

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  • Department of Endocrinology and Metabolism, Jiangxi Province People's Hospital, Jiangxi Nanchang 330006, China

Received date: 2016-06-20

  Online published: 2017-04-25

Abstract

Objective: To investigate the correlation between blood pressure level and development and progression of chronic kidney disease (CKD) in Chinese community diabetes (DM) patients. Methods: Questionnaires and physical examination were performed in 1 349 diabetic patients over 40 years old in a community in Nanchang. The laboratory examinations included blood sugar and blood lipids, and the estimated glomerular filtration rate (estimated GFR, eGFR) was calculated. Patients were grouped by blood pressure level on the basis for every 10 mmHg. Logistic regression was used to evaluate the correlation between different groups. Results: The prevalence of CKD in community DM patients was 28.97%(376/1298), and the prevalence of CKD in subjects with hypertension was 83.51%(314/376). The treated rate of hypertension was 95.21%(299/314), and the hypertension control rate was 49.33%(155/314). Non-conditional logistic regression analysis showed that age, BMI, duration of diabetes, glycosylated hemoglobin, systolic blood pressure, low density lipoprotein cholesterol(LDL-C), smoking, taking meals at restaurant weekly were correlated with CKD in community diabetic patients. The prevalence of CKD in community patients with DM increased with the elder age, longer duration of dia-betes, higher glycated hemoglobin, larger body mass index, higher LDL-C, smoking, and higher frequency of taking meals at restaurant weekly. CKD staging was different between systolic blood pressure≥; 130 mmHg and<; 130 mmHg, as well as between systolic blood pressure ≥; 140 mmHg and <; 140 mmHg. There was also significant difference in progress of renal disease between patients having diastolic blood pressure <; 80 mmHg and ≥; 80 mmHg. Conclusions: CKD is a common complication of DM, and CKD is associated with a high prevalence rate and low control rate of hypertension. Age, duration of diabetes, glycosylated hemoglobin, body mass index(BMI), LDL-C, smoking and taking meals at restaurant weekly are correlated with the stage and progress of chronic kidney disease (CKD) and control of hypertension.

Cite this article

LIN Anhua, WANG Chenxiu, HUO Yanan, CHEN Zhixiong, SONG Wei, LIU Jingdong, HU Yaqin . Correlation of blood pressure level with development and progression of chronic kidney disease in Chinese community diabetes patients[J]. Journal of Diagnostics Concepts & Practice, 2017 , 16(02) : 178 -182 . DOI: 10.16150/j.1671-2870.2017.02.011

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