Journal of Diagnostics Concepts & Practice >

2020 , Vol. 19 >Issue 03: 297 - 302

DOI: https://doi.org/10.16150/j.1671-2870.2020.03.017

Original article

Correlation of estimated glomerular filtration rate with incidence of in-stent restenosis in patients with drug-elu-ting stent

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  • 1. Department of Cardiology, Rujin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
    2. Department of Cardiology,Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China

Received date: 2020-04-25

  Online published: 2020-06-25

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Abstract

Objective: To evaluate correlation of estimated glomerular filtration rate with occurrence of in-stent restenosis (ISR) in patients treated with drug-eluting stent(DES) implantation during follow-up period. Methods: Patients undergone DES implantation in the RIPPER study between January 2010 and July 2016 were enrolled, and coronary angiography was performed again to detect ISR after 12-24 months (with the average time of 13 months). Binary Logistics regression were used to assess the risk factors for in-stent restenosis (ISR), and evaluate the correlation of eGFR with ISR in patients. Results: A total of 1 790 patients meeting the inclusion criteria, with the average eGFR of 89.97 mL/(min·1.73 m2) during follow-up, were divided into ISR group (n=200) and No-ISR group (n=1 590). The eGFR in ISR group was significantly lower than No-ISR group [(86.50±25.69) mL/(min·1.73 m2) vs. (90.64±26.59) mL/(min·1.73 m2), P=0.038]. Binary Logistics regression showed that the risk factors for ISR were number of implanted stent[OR=1.478, 95% CI 1.177-1.855, P=0.001] and increased baseline C-reactive protein level [OR=1.006, 95%CI 1.002-1.011, P=0.007], while relatively elevated eGFR during follow-up was protective factor（OR=0.990, 95%CI 0.982-0.999, P=0.022.Conclusions: In patients with nearly normal eGFR after DES implantation, relatively lower eGFR is correlated with the incidence of ISR.

Key words： Estimated glomerular filtration rate; Drug eluting stent; Restenosis; Logistics regression

Cite this article

LIU Shengjun, LIU Lili, ZHU Zhengbin, SUN Yi, ZHU Tianqi, FENG Shuo, CHEN Xin, QUAN Weiwei, ZHANG Ruiyan . Correlation of estimated glomerular filtration rate with incidence of in-stent restenosis in patients with drug-elu-ting stent[J]. Journal of Diagnostics Concepts & Practice, 2020 , 19(03) : 297 -302 . DOI: 10.16150/j.1671-2870.2020.03.017

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