Journal of Diagnostics Concepts & Practice >

2019 , Vol. 18 >Issue 03: 353 - 359

DOI: https://doi.org/10.16150/j.1671-2870.2019.03.021

Original articles

Clinical value of serum procalcitonin in patients of chronic kidney disease with bacterial infection

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  • Department of Nephrology, First Affiliated Hospital of China Medical University, Liaoning Shenyang 110000, China

Received date: 2018-11-01

  Online published: 2019-06-25

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Abstract

Objective: Clinical data of chronic kidney disease(CKD) patients (n=354) of different disease stages were collected to analyze the median serum procalcitonin (PCT) level and diagnostic value of serum PCT in CKD patients with bacterial Infection. Methods: A total of 354 CKD patients admitted to the First Affiliated Hospital of China Medical University, including 153 patients with bacterial infection and antibiotics treatment and 201 patients without infection, were enrolled in this study. According to eGFR, patients were divided into stage 1, stage2, stage3, stage4, stage5 with nondialysis andstage5 with hemodialysis (HD) groups. Spearman correlation was used to analyze the relationship between PCT and serum creatinine and eGFR. ROC curve was used to analyze the diagnostic efficacy of serum PCT in different stage CKD patients with bacterial infection. Multivariate logistic regression analysis was used to assess the impact factors of infection. Results: The serum PCT level of CKD patients with infection was significantly higher than that of non-infected. The dynamic change of PCT was in parallel with recovery of clinical infection.PCT was positively correlated with serum creatinine, and negatively correlated with eGFR. Serum PCT cutoff values for differentiating infection and non-infection in overall CKD, stage 3, stage 4, stage 5 with nodialysis and with hemodialysis (HD) groups were 0.40 ng/mL,0.12 ng/mL, 0.23 ng/mL, 0.28 ng/mL and 0.60 ng/mL, respectively. Logistic regression analysis showed, WBC, PCT, CRP and serum albumin were independent risk factors for infection. Conclusions: PCT can be used as a useful clinical indicator of infection in different stages of CKD; the dynamic change of PCT has important diagnostic value in the diagnosis and treatment of CKD patients.

Key words： Procalcitonin; Chronic kidney disease; Bacterial Infection; C-reactive protein; Diagnosis

Cite this article

WANG Yuanyuan, FAN Qiuling . Clinical value of serum procalcitonin in patients of chronic kidney disease with bacterial infection[J]. Journal of Diagnostics Concepts & Practice, 2019 , 18(03) : 353 -359 . DOI: 10.16150/j.1671-2870.2019.03.021

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