Objective: To evaluate the clinicopathologic features and prognosis of intraductal papillary mucinous neoplasm with an associated invasive carcinoma of the pancreas. Methods: The clinical data, pathological features and prognosis of 52 patients were studied retrospectively. Results: Of all the 52 cases, 36 lesions were located in the head of pancreas, 15 were in the body/tail, and 1 was in the entire length of the pancreatic duct. The median age of these patients was 65 years. Of the 52 IPMNs, 23 cases were the gastric type, 12 cases were intestinal, 9 cases were pancreatobiliary, 7 cases were mixed type (gastric+pancreatobiliary type) and 1 case was oncocytic. The types of invasive carcinoma included 37 cases of ductal adenocarcinomas, 13 cases of colloid carcinomas, 1 cases of undifferentiated carcinoma and 1 cases of adenosquamous carcinoma. Elevated serum CA19-9 level was more frequent in patients with ductal adenocarcinoma. Nine of 52 patients were lost to follow-up. The median postoperative follow-up period was 16 months (range 5-57 months). Conclusions: The intraductal papillary mucinous neoplasm with an associated invasive carcinoma of the pancreas are mainly ductal adenocarcinoma. Elevated serum CA19-9 level is associated with the types of the invasive carcinoma. The positive lymph nodes and tumor extending beyond pancreas are risk factors for the poor prognosis.
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