Objective: To study the clinnicopathological features, differential diagnosis and prognosis of primary renal angiosarcoma. Methods: Tumor specimens from 3 cases of primary renal angiosarcoma were observed under light microscope. Immunohistochemistry examination was performed and relevant literatures were reviewed. Results: The lesions didn't have a clear boundary between tumor and normal tissue, and multiple irregular anastomosing vascular spaces or channels which were lined by discrete and large endothelial cells with variable degrees of nuclear atypia were observed. Two cases had epithelioid characteristics. Immunohistochemical study showed that tumor cells were positive for vimentin, CD31, CD34. Tumor cells of Case 2 were also partially positive for EMA. Tumor cells of Case 3 were strongly and diffusely positive for AE1/AE3, CK8/18. Tumor cells of Case 1 were negative for AE1/AE3, EMA. Conclusions: Primary renal angiosarcoma is extremely rare, and imaging examination does not allow for specific diagnosis of the tumor. Histopathology and immunohistochemistry are of great importance for diagnosis of the tumor. Whole intact tumor resection is the most effective treatment for primary renal angiosarcoma.
HAN Dongyan, LI Qianyu, JIANG Hongwei, XI Hao, WEI Qing
. Clinicopathological features of primary renal angiosarcoma: report of 3 cases and review of literature[J]. Journal of Diagnostics Concepts & Practice, 2017
, 16(02)
: 183
-187
.
DOI: 10.16150/j.1671-2870.2017.02.012
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