Original articles

2017-2020 survey of HPV infection subtypes in the cervical exfoliated cells in Shanghai

Expand
  • a. Department of Clinical Laboratory, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
    b. Department of Gynaecology and Obstetrics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China

Received date: 2021-02-18

  Online published: 2021-12-25

Abstract

Objective: To survey the status of infection of human papillomavirus (HPV) in cervical exfoliated cells and identify the local epidemiological characteristics of HPV infections. Methods: The HPV subtype test was carried out on cervical exfoliated cells obtained from 58 883 female subjects in the gynecological clinic and physical examination center from October 2017 through December 2020. The results were retrospectively reviewed and distribution of 25 common HPV subtypes in patients of different age groups and with different types of cervical disease (chronic cervicitis, cervical neoplasia, cervical malignant tumor) were analyzed. Results: Of 58 883 female subjects surveyed, 9 168(15.57%) cases were positive for HPV infection, including 6 971 single infection cases and 2 197 multiple infection cases. The HPV52 (3.31%), HPV58 (2.05%), and HPV16 (1.92%) were subtypes mostly detected. The HPV infection rate in females aged under 20 (37.34%) and between 21-30 (19.52%) were significantly higher than subjects of other age groups. Of 2 105 patients with cervical lesions, the HPV52 (16.92%), HPV58 (10.68%) and HPV16 (10.16%) were mostly identified in patients with chronic cervicitis; the HPV52 ( 22.22%), HPV16 (17.46%), HPV58 (14.29%) were mostly associated with cervical epithelial neoplasia; and the HPV16 (29.59%), HPV52 (11.24%), HPV58 (10.06%) were the most common subtypes detected in patients with cervical malignant tumors. Conclusions: The HPV infection rate in females of Shanghai is 15.57%, and the HPV52, HPV58, and HPV16 are the predominant subtypes detected. The three subtypes are also highly associated with patients with cervical lesions and cervical cancer, which indicates that the HPV52, HPV58, and HPV16, instead of HPV16 and HPV18 suggested in foreign epidemic studies, are the carcinogenic subtypes of HPV in Shanghai.

Cite this article

MENG Jun, XU Xiaosheng, LU Yiyi, FAN Zhenjia, CAI Gang . 2017-2020 survey of HPV infection subtypes in the cervical exfoliated cells in Shanghai[J]. Journal of Diagnostics Concepts & Practice, 2021 , 20(06) : 567 -572 . DOI: 10.16150/j.1671-2870.2021.06.010

References

[1] Chinchai T, Chansaenroj J, Swangvaree S, et al. Prevalence of human papillomavirus genotypes in cervical cancer[J]. Int J Gynecol Cancer, 2012, 22(6):1063-1068.
[2] 赵超, 李静, 屠铮, 等. 北京社区妇女生殖道人乳头瘤病毒感染及子宫颈上皮内瘤变流行病学调查[J]. 中华流行病学杂志, 2007, 28(10):947-950.
[3] 缪应新, 甘洁民, 陈洁, 等. 上海地区人乳头瘤病毒基因芯片法分型检测的临床意义[J]. 检验医学, 2015, 30(6):595-598.
[4] Zhao Y, Wu K, Tong H, et al. Genotype patterns and prevalence of human papilloma virus in non-vaccinated women in Zunyi, China[J]. Saudi Med J, 2018, 39(6):572-578.
[5] Yeo-Teh NSL, Ito Y, Jha S. High-risk human papillomaviral oncogenes E6 and E7 target key cellular pathways to achieve oncogenesis[J]. Int J Mol Sci, 2018, 19(6):1706.
[6] Tjalma WA, Depuydt CE. Cervical cancer screening: which HPV test should be used--L1 or E6/E7?[J]. Eur J Obstet Gynecol Reprod Biol, 2013, 170(1):45-46.
[7] Burd EM. Human papillomavirus and cervical cancer[J]. Clin Microbiol Rev, 2003, 16(1):1-17.
[8] Walboomers JM, Jacobs MV, Manos MM, et al. Human papillomavirus is a necessary cause of invasive cervical cancer worldwide[J]. J Pathol, 1999, 189(1):12-19.
[9] Wei B, Mei P, Huang S, et al. Evaluation of the sureX HPV genotyping test for the detection of high-risk HPV in cervical cancer screening[J]. Virol J, 2020, 17(1):171.
[10] 黄路遥, 许燕燕, 娄晓丽, 等. 上海市松江区人乳头瘤病毒感染情况分析[J]. 检验医学, 2017, 32(8):695-699.
[11] 肖林林, 赵卫卫, 彭攸, 等. 区域内HPV亚型分布特点及其与宫颈病变的关系[J]. 国际检验医学杂志, 2017, 38(3):360-362,365.
[12] Wang R, Guo XL, Wisman GB, et al. Nationwide prevalence of human papillomavirus infection and viral genotype distribution in 37 cities in China[J]. BMC Infect Dis, 2015, 15:257.
[13] 姜丹, 叶劲东, 张晓平, 等. 深圳市万名流动妇女HPV感染现状分析[J]. 中国公共卫生管理, 2012, 28(6):796-798.
[14] Li J, Kang LN, Qiao YL. Review of the cervical cancer disease burden in mainland China[J]. Asian Pac J Cancer Prev, 2011, 12(5):1149-1153.
[15] Zhao R, Zhang WY, Wu MH, et al. Human papillomavirus infection in Beijing, People′s Republic of China: a population-based study[J]. Br J Cancer, 2009, 101(9):1635-1640.
[16] Althoff KN, Paul P, Burke AE, et al. Correlates of cervicovaginal human papillomavirus detection in perimenopausal women[J]. J Womens Health (Larchmt), 2009, 18(9):1341-1346.
[17] 李霓, 张思维, 陈万青, 等. 亚洲妇女宫颈癌中人乳头状瘤病毒型别分布的Meta分析[J]. 中国肿瘤, 2010, 19(3):195-202.
Outlines

/