Objective: To study the expression of SOX-2 (sex determining region Y-box) in breast invasive carcinoma of no special type (ICNST) and analyze its significance and relationship with ER, PR, Her-2, Ki-67 and clinicopathological features. Methods: Normal breast tissue specimens (30 cases) and ICNST specimens of 179 patients and their complete clinical and pathological data during the period from January 2005 to December 2012 at Nanjing General Hospital of Nanjing Military Command were collected. The clinicopathological features included age, menstrual status, clinical stage, recurrence, metastasis, death, and expressions of ER, PR, Ki-67 and Her-2. The expressions of SOX-2, ER, PR, Ki-67 and Her-2 were detected by immunohistochemistry. Analysis of the clinicopathological features in association with SOX-2 expression was performed. Results: The expression of SOX-2 was significantly higher in ICNST cancer tissues than that in normal breast tissue (P<0.05). SOX-2 expression in ICNST was correlated with recurrence, lymph node metastasis and clinical staging (P<0.05), while had no significant correlation with histological grade, age, menopausal status, tumor size, ER, PR, Her-2, Ki-67 and molecular typing. Kaplan-Meier analysis showed that disease free survival time and total survival time in SOX-2 positive group were shorter than that in SOX-2 negative group (P<0.05). COX analysis revealed that SOX-2 was an independent prognostic factor affecting disease-free survival of ICNST(P<0.05). Conclusions: The expression of SOX-2 is closely correlated with occurrence, progression, recurrence and metastasis of ICNST. It may become an important biological marker for evaluating the prognosis of breast cancer and create new ideas for breast cancer research.
LU Shuxiong, CHENG Kai, CAI Li, ZHOU Xiaodie, WANG Jianjun, WANG Xuan, SHI Qunli
. Expression of SOX-2 in breast invasive carcinoma of no special type and its clinical and pathological significance[J]. Journal of Diagnostics Concepts & Practice, 2018
, 17(06)
: 701
-706
.
DOI: 10.16150/j.1671-2870.2018.06.014
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