Objective: To investigate clinical significance of detections of fibrinogen (FIB), D-dimer (DD), antithrombin Ⅲ(AT-Ⅲ), protein C (PC) and protein S (PS) in plasma of patients with different degrees of cirrhosis. Methods: A total of 418 patients with cirrhosis treated in our hospital from October 2019 to June 2021 were enrolled as the observation group, including 138 patients with cirrhosis at the compensatory stage and 280 patients with cirrhosis at the decompensa-ted stage. Meanwhile, 115 healthy people who underwent physical examination during the same period were served as control group. The activities of FIB, DD, AT-Ⅲ, PC and PS were detected, and the differences in coagulation indictors between the cirrhosis compensatory group, the cirrhosis decompensated group and the normal control group were analyzed. Results: The activities of anticoagulant factors AT-Ⅲ, PC and PS in cirrhosis group were significantly decreased, than those with normal control group (P<0.01), and there were significant differences between compensatory group and decompensated group (P<0.01). There was no significant difference in DD and FIB between compensatory cirrhosis group and healthy control group (P=0.061 and P=0.270), but there was significant difference in DD and FIB between compensatory cirrhosis group and decompensated cirrhosis group (P<0.01). The area under curve (AUC) of receiver operating cha-racteristic (ROC curve) of AT-Ⅲ, PC, PS for distingiushing liver cirrhosis patients from health controls, liver decormpenation and liver compensation were 0.947, 0.952, and 0.935, and 0.786, 0.657 and 0.761. Conclusions: Besides FIB, DD and AT-Ⅲ, PC and PS activity are correlated with the severity of cirrhosis. In the early stage of cirrhosis, FIB and DD levels do not change significantly,but AT-Ⅲ, PC activity and PS activity change significantly. Therefore, dynamic combined detection of FIB, DD, AT-Ⅲ, PC activity and PS activity in patients with cirrhosis is helpful to monitoring development of the disease.