Journal of Diagnostics Concepts & Practice >
Expression of microRNA-337-3p in oral squamous cell carcinoma and its clinical significance
Received date: 2020-03-23
Online published: 2022-07-14
Objective: To investigate the expression of microRNA (miRNA)-337-3p in oral squamous cell carcinoma (OSCC) and its clinical significance. Methods: The expression of miRNA-337-3p in OSCC cancer and paracancerous tissue of 20 OSCC patients was determined, and the correlation of miRNA-337-3p expression with clinical-pathological parameter was analyzed. Scratch test was performed to detect the effect of miRNA-337-3p on migration ability of OSCC cell line HN30 cells, and the possible molecular mechanism was explored. Results: Expression of miRNA-337-3p in OSCC was significantly lower than that in paracancerous tissue(P<0.000 1), and was correlated significantly with the status of lymph node metastasis (P<0.05). Patients with lymph node metastasis (N1+N2) had a lower expression level of miRNA-337-3p than those without lymph node metastasis (N0). Overexpression of miRNA-337-3p in HN30 cells inhibited cell migration, whereas suppression of miRNA-337-3p led to increase of cell migration. miRNA-337-3p could inhibit the expression of matrix metalloproteinase-14 (MMP-14). Conclusions: miRNA-337-3p plays a suppressive role in OSCC, inhibitingthe invasion and metastasis of OSCC cells, and is expected to be used as a biomarker for assessing the invasion and metastasis of OSCC and helping the monitoring of prognosis.
Key words: Oral squamous cell carcinoma; microRNA; microRNA-337-3p; Metastasis
ZHANG Xingming, GU Wenli . Expression of microRNA-337-3p in oral squamous cell carcinoma and its clinical significance[J]. Journal of Diagnostics Concepts & Practice, 2020 , 19(05) : 510 -515 . DOI: 10.16150/j.1671-2870.2020.05.012
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