Original articles

Correlation between gene polymorphism of chromosome 3q26 rs12696304 and 1-year survival rate after acute heart failure in an elderly Han population in South China

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  • 1. Department of General Surgery, the Affiliated Jiangning Hospital of Nanjing Medical University, Jiangsu Nanjin 211100
    2a. ICU, 2b. Department of Cardiology, First Affiliate Hospital of Nanjing Medical University, Jiangsu Nanjin 210029, China

Received date: 2020-09-23

  Online published: 2022-07-14

Abstract

Objective: To investigate the correlation between the gene polymorphism of rs12696304 in chromosome 3q26 and 1-year survival rate in the patients with acute heart failure (AHF). Methods: A total of 336 elderly patients of Han population in South China (aged≥60 years) with AHF were enrolled during March 2012 and April 2016. DNA of each patient was extracted from peripheral blood, and the gene polymorphism of rs12696304 was analyzed by real-time fluorescence quantitative PCR with TaqMan probe. One-year survival rate was compared between the patients with diffe-rent gene typing in multiple genetic models using Kaplan-Meier and log-rank test. The Cox regression analysis was used to assess relation between the gene polymorphism of rs12696304 and 1-year survival rate in the patients with AHF. Results: In the co-dominant genetic model, the 1-year survival rate of the AHF patients carrying heterozygous CG genotypes was lower than that of patients carrying wild homozygous GG genotypes (74.8% vs 85.4%, P=0.027). In the dominant genetic model, 1-year survival rate of the AHF patients carrying CG+CC genotype was significantly lower than that of patients carrying the wild homozygous GG genotype (74.9% vs 85.4%, P=0.023). Further Cox regression analysis showed that the risk of 1-year death in the AHF patients carrying CG+CC genotype was 2.45 times of that in the patients with GG genotype (HR=2.45, 95%CI: 1.22-4.95, P=0.012) after adjustment with the relevant variables in codominant model, and in the dominant model, the risk of 1-year death was also 2.45 times of that in patients with GG genotype (HR=2.45, 95%CI: 1.24-4.84, P=0.010). Conclusions: The gene polymorphisms of rs12696304 located in chromosome 3q26 region may be associated with the 1-year prognosis in the patients with AHF.

Cite this article

ZHANG Zhongwen, ZUO Xiangrong, ZHENG Xuhui, CAO Quan, Li Xinli, LI Yanxiu . Correlation between gene polymorphism of chromosome 3q26 rs12696304 and 1-year survival rate after acute heart failure in an elderly Han population in South China[J]. Journal of Diagnostics Concepts & Practice, 2020 , 19(06) : 565 -571 . DOI: 10.16150/j.1671-2870.2020.06.004

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