Journal of Diagnostics Concepts & Practice >

2020 , Vol. 19 >Issue 04: 359 - 363

DOI: https://doi.org/10.16150/j.1671-2870.2020.04.007

Original articles

Diagnostic accuracy of ultrasound-guided fine needle aspiration biopsy for different thyroid carcinoma in 10 388 thyroid nodules: a ten-year study

Expand
  • Department of Ultrasound, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China

Received date: 2020-07-01

  Online published: 2022-07-15

Fold

Abstract

Objective: To investigate the diagnostic accuracy of ultrasound-guided fine needle aspiration biopsy (US-FNAB) in different subtypes of thyroid carcinoma. Methods: A total of 10 388 thyroid nodules from 9 933 patients undergone US-FNAB in Ruijin Hospital, Shanghai Jiao Tong University School of Medicine from January 2010 to December 2019 were enrolled, and related data were retrospectively analyzed. The sensitivity, specificity, accuracy, positive and negative predictive value of US-FNAB for thyroid carcinoma were assessed by comparing to the results of surgical pathology. The accuracy rate of diagnosis between different subtypes of thyroid carcinoma was further analyzed. Results: The ten-year study revealed that among 10 388 nodules, 9 379 nodules were malignant. The total sensitivity, specificity, positive and negative predictive value of US-FNAB for thyroid carcinoma were 95.4%, 84.7%, 98.4%, 65.9% and 94.4%, respectively. For the subtypes of thyroid carcinoma, diagnostic accuracies for papillary carcinoma and medullary carcinoma were 95.8% and 69.4%, respectively. Conclusions: US-FNAB is valuable in the diagnosis of thyroid nodules and has the highest diagnostic accuracy for thyroid papillary carcinoma.

Key words： Thyroid carcinoma; Ultrasound-guided fine needle aspiration biopsy; Papillary carcinoma of thyroid

Cite this article

WANG Xing, WANG Ronghui, ZHANG Guiping, DONG Yijie, ZHOU Wei, ZHAN Weiwei . Diagnostic accuracy of ultrasound-guided fine needle aspiration biopsy for different thyroid carcinoma in 10 388 thyroid nodules: a ten-year study[J]. Journal of Diagnostics Concepts & Practice, 2020 , 19(04) : 359 -363 . DOI: 10.16150/j.1671-2870.2020.04.007

References

[1] Hughes DT, Haymart MR, Miller BS, et al. The most commonly occurring papillary thyroid cancer in the Uni-ted States is now a microcarcinoma in a patient older than 45 years[J]. Thyroid, 2011, 21(3):231-236.
[2] Kowalska A, Walczyk A, Kowalik A, et al. Increase in papillary thyroid cancer incidence is accompanied by changes in the frequency of the BRAF V600E mutation: a single-institution study[J]. Thyroid, 2016, 26(4):543-551.
[3] Morris LG, Tuttle RM, Davies L. Changing trends in the incidence of thyroid cancer in the United States[J]. JAMA Otolaryngol Head Neck Surg, 2016, 142(7):709-711.
[4] Han L, Wu Z, Li W, et al. The real world and thinking of thyroid cancer in China[J]. IJS Oncology, 2019, 4(7):e81.
[5] Chen W, Zheng R, Baade PD, et al. Cancer statistics in China, 2015[J]. CA Cancer J Clin, 2016, 66(2):115-132.
[6] Haugen BR, Alexander EK, Bible KC, et al. 2015 Ame-rican Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer: The American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer[J]. Thyroid, 2016, 26(1):1-133.
[7] Danese D, Sciacchitano S, Farsetti A, et al. Diagnostic accuracy of conventional versus sonography-guided fine-needle aspiration biopsy of thyroid nodules[J]. Thyroid, 1998, 8(1):15-21.
[8] American Thyroid Association (ATA) Guidelines Taskforce on Thyroid Nodules and Differentiated Thyroid Cancer, Cooper DS, Doherty GM, et al. Revised American Thyroid Association Management Guidelines for Patients with Thyroid Nodules and Differentiated Thyroid Cancer[J]. Thyroid, 2009, 19(11):1167-1214.
[9] Ali SZ, Cibas ES. The Bethesda system for reporting thyroid cytopathology Ⅱ[J]. Acta Cytol, 2016, 60(5):397-398.
[10] 彭丽, 顾明君. Meta分析比较常规和超声引导下甲状腺细针穿刺细胞学检查对甲状腺结节的诊断价值[J]. 第二军医大学学报, 2007, 28(9):968-972.
[11] Shin JH, Baek JH, Chung J, et al. Ultrasonography diagnosis and imaging-based management of thyroid nodules: revised Korean Society of Thyroid Radiology Consensus Statement and Recommendations[J]. Korean J Radiol, 2016, 17(3):370-395.
[12] Tessler FN, Middleton WD, Grant EG, et al. ACR Thyroid Imaging, Reporting and Data System (TI-RADS): White Paper of the ACR TI-RADS Committee[J]. J Am Coll Radiol, 2017, 14(5):587-595.
[13] Wémeau JL, Sadoul JL, d'Herbomez M, et al. Guidelines of the French Society of Endocrinology for the Management of Thyroid Nodules[J]. Ann Endocrinol (Paris), 2011, 72(4):251-281.
[14] Baskin HJ, Duick DS. The endocrinologists' view of ultrasound guidelines for fine needle aspiration[J]. Thyroid, 2006, 16(3):207-208.
[15] Gharib H, Papini E, Garber JR, et al. American Association of Clinical Endocrinologists, American College of Endocrinology, and Associazione Medici Endocrinologi Medical Guidelines for Clinical Practice for the Diagnosis and Management of Thyroid Nodules- -2016 Update[J]. Endocr Pract, 2016, 22(5):622-639.
[16] Ke J, Jianyong L, Ying L, et al. The use of The Bethesda System for Reporting Thyroid Cytopathology in a Chinese population: an analysis of 13 351 specimens[J]. Diagn Cytopathol, 2019, 47(9):876-880.
[17] Zhu Y, Song Y, Xu G, et al. Causes of misdiagnoses by thyroid fine-needle aspiration cytology (FNAC): our experience and a systematic review[J]. Diagn Pathol, 2020, 15(1):1.
[18] Zhu Y, Song Y, Xu G, et al. The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC): a report of 2,781 cases in a Chinese population[J]. Chin J Cancer Res, 2020, 32(2):140-148.
[19] Furlan JC, Bedard YC, Rosen IB. Role of fine-needle aspiration biopsy and frozen section in the management of papillary thyroid carcinoma subtypes[J]. World J Surg, 2004, 28(9):880-885.
[20] DeLellis RA. Pathology and genetics of tumours of endocrine organs[M]. Lyon: IARC Press, 2004.
[21] Ali SZ, Cibas ES, SpringerLink(Online service). The Bethesda system for reporting thyroid cytopathology definitions, criteria and explanatory notes[M]. Boston, MA: Springer Science+Business Media, LLC, 2010.
[22] Trimboli P, Treglia G, Guidobaldi L, et al. Detection rate of FNA cytology in medullary thyroid carcinoma: A meta-analysis[J]. Clin Endocrinol (Oxf), 2015, 82(2):280-285.
[23] Ghofrani M, Ocal IT. Medullary thyroid carcinoma: a brief review of pathogenesis, diagnosis, and treatment[J]. Pathology Case Reviews, 2015, 20:204-209.
[24] Trimboli P, Cremonini N, Ceriani L, et al. Calcitonin measurement in aspiration needle washout fluids has higher sensitivity than cytology in detecting medullary thyroid cancer: a retrospective multicentre study[J]. Clin Endocrinol(Oxf), 2014, 80(1):135-140.
[25] Mathur A, Olson MT, Zeiger MA. Follicular lesions of the thyroid[J]. Surg Clin North Am, 2014, 94(3):499-513.
Options
Outlines

/

〈 〉