Objective: To analyze the relationship between gene polymorphism of chromosome region 9p21 (rs10757274, rs7044859, rs4977574 and rs496892) and carotid plaque in acute non-cardioembolic cerebral infarction patients. Methods: The gene polymorphisms of site rs10757274, rs7044859, rs4977574 and rs496892 in chromosome region 9p21 were analyzed with polymerase chain reaction-ligase detection reaction (PCR-LDR) in 411 acute non-cardioembolic cerebral infarction patients (230 with carotid plaque while 181 without). Results: Compared with those without carotid plaque, an increased frequency in the G allele of rs4977574 was seen in patients with carotid plague group(52.6% vs 41.7%) (adjusted P=0.006), as well as the frequency in GG allele of rs4977574 genotype (26.5% vs 20.4%) (P=0.002). Strong linkage disequilibrium existed not only between rs10757274 and rs4977574, but also between rs7044859 and rs496892. Conclusions: Genetic polymorphism of rs4977574 on 9p21 is potentially associated with carotid plaque in patients with non-cardioembolic cerebral infarction in Xinjiang and Shanghai.
MAIMAITI Yiming, RE Xidan, CHEN Bo, ZHANG Xiang, MA Weiying, YANG Kang, FU Yi
. Analysis on relationship between polymorphism of chromosome region 9p21 and susceptibility of carotid plaque in acute non-cardioembolic cerebral infarction patients[J]. Journal of Diagnostics Concepts & Practice, 2016
, 15(05)
: 498
-502
.
DOI: 10.16150/j.1671-2870.2016.05.013
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