Journal of Diagnostics Concepts & Practice >

2016 , Vol. 15 >Issue 06: 595 - 601

DOI: https://doi.org/10.16150/j.1671-2870.2016.06.010

Original articles

Dietary fat and risk of endometrial cancer: A meta-analysis

Expand
  • 1. Department of Neurosurgery, The First Affiliated Hospital, Nanjing Medical University, Jiangsu Nanjing 210029, China;
    2. Department of Neurosurgery, Shengze Hospital of Jiangsu Province, Jiangsu Suzhou 215228, China

Received date: 2016-06-08

  Online published: 2022-07-27

Fold

Abstract

Objective: To evaluate the relationship between dietary fat and risk of endometrial cancer (EC). Methods: This meta-analysis was a systematic review of literature published up to June, 2016. Data from PubMed, Web of Science, EMbase, CBM, VIP, and WanFang Data were retrieved and analyzed the relationship between dietary fat and risk of endometrial cancer. All literatures retrieved were screened and extracted according to the inclusion and exclusion criteria by two researchers independently using Stata 11.0 software. The meta-analysis was performed by study design of fat types (total fat, saturated fat, monounsaturated fat and polyunsaturated fat). Results: A total of 15 studies involving 6 480 participants were included. Compared with low intake of fat, high intake of total fat, saturated fat led to a higher risk of endometrial cancer [OR=1.22, 95%CI: 1.02-1.46; OR=1.21, 95%CI: 1.00-1.41]. According to subgroup analysis, the OR for case-control studies were 1.39 (95%CI: 1.14-1.70) in total fat and 1.34 (95%CI: 1.13-1.60) in saturated fat. The summarized RR based on cohort studies was 0.80(0.65-0.98) for total fat. Positive correlation between dietary saturated fat intake and risk of endometrial cancer was observed in studies in United States (OR=1.39, 95%CI: 1.00-1.93), also with high total energy intake（OR=2.17, 95%CI: 1.57-2.99) and smokers(OR=1.30, 95%CI: 1.04-1.62). Conclusions: The meta-analysis of case-control studies reveal that high intake of total fat and saturated fat increase the risk of endometrial cancer. The results of subtype analysis also indicate that high saturated fat intake might increase the risk of endometrial cancer in smoking and high energy intake group. Additional experimental and epidemiological studies with larger participants worldwide are necessary to validate the association between fat intake and risk of endometrial cancer.

Key words： Fat; Endometrial cancer; Literature review; Meta-analysis

Cite this article

WANG Jin, WANG Songtao, LIU Xiaoyang, HONG Yongzhi, ZHAO Peng . Dietary fat and risk of endometrial cancer: A meta-analysis[J]. Journal of Diagnostics Concepts & Practice, 2016 , 15(06) : 595 -601 . DOI: 10.16150/j.1671-2870.2016.06.010

References

[1] Ferlay J, Soerjomataram I, Ervik M, et al. (2013) GLOBOCAN 2012 v1.0, Cancer Incidence and Mortality Worldwide[R/OL]. France: Lyon,[2016-05-20]. http://globocan.iarc.fr.
[2] Bruning PF, Bonfrèr JM, et al.Free fatty acid concentrations correlated with the available fraction of estradiol in human plasma[J]. Cancer Res,1986,46(5):2606-2609.
[3] Nagaoka T, Onodera H, Hayashi Y, et al.Influence of high-fat diets on the occurrence of spontaneous uterine endometrial adenocarcinomas in rats[J]. Teratog Carcinog Mutagen,1995,15(4):167-177.
[4] McCann SE, Freudenheim JL, Marshall JR, et al. Diet in the epidemiology of endometrial cancer in western New York (United States)[J]. Cancer Causes Control,2000, 11(10):965-974.
[5] Tzonou A, Lipworth L, Kalandidi A, et al.Dietary factors and the risk of endometrial cancer: a case--control study in Greece[J]. Br J Cancer,1996,73(10):1284-1290.
[6] Zheng W, Kushi LH, Potter JD, et al.Dietary intake of energy and animal foods and endometrial cancer incidence. The Iowa women's health study[J]. Am J Epidemiol,1995,142(4):388-394.
[7] Barbone F, Austin H, Partridge EE, et al.Diet and endometrial cancer: a case-control study[J]. Am J Epide-miol,1993,137(4):393-403.
[8] Potischman N, Hoover RN, Brinton LA, et al.Case-control study of endogenous steroid hormones and endometrial cancer[J]. J Natl Cancer Inst,1996,88(16):1127-1135.
[9] Swanson CA, Potischman N, Barrett RJ, et al.Endometrial cancer risk in relation to serum lipids and lipoprotein levels[J]. Cancer Epidemiol Biomarkers Prev,1994,3(7):575-581.
[10] Sturgeon SR, Brock JW, Potischman N, et al.Serum concentrations of organochlorine compounds and endometrial cancer risk (United States)[J]. Cancer Causes Control,1998,9(4):417-424.
[11] Potischman N, Swanson CA, Brinton LA, et al.Dietary associations in a case-control study of endometrial cancer[J]. Cancer Causes Control,1993,4(3):239-250.
[12] Dalvi TB, Canchola AJ, Horn-Ross PL, et al.Dietary patterns, Mediterranean diet, and endometrial cancer risk[J]. Cancer Causes Control,2007,18(9):957-966.
[13] la Vecchia C, Decarli A, Fasoli M, et al. Nutrition and diet in the etiology of endometrial cancer[J]. Cancer, 1986,57(6):1248-1253.
[14] la Vecchia C, Decarli A, Negri E, et al. Epidemiological aspects of diet and cancer: a summary review of case-control studies from northern Italy[J]. Oncology,1988,45(5):364-370.
[15] Petridou E, Kedikoglou S, Koukoulomatis P, et al.Diet in relation to endometrial cancer risk: a case-control study in Greece[J]. Nutr Cancer,2002,44(1):16-22.
[16] Zhang CY, Wang TG.A case-control study of endometrial cancer in Beijing[J]. Zhonghua Liu Xing Bing Xue Za Zhi,1989,10(4):235-237.
[17] Villani C, Pucci G, Pietrangeli D, et al.Role of diet in endometrial cancer patients[J]. Eur J Gynaecol Oncol, 1986,7(2):139-143.
[18] Lissner L, Kroon UB, Björntorp P, et al.Adipose tissue fatty acids and dietary fat sources in relation to endometrial cancer: a retrospective study of cases in remission, and population-based controls[J]. Acta Obstet Gynecol Scand,1993,72(6):481-487.
[19] Jain MG, Rohan TE, Howe GR, et al.A cohort study of nutritional factors and endometrial cancer[J]. Eur J Epidemiol,2000,16(10):899-905.
[20] Cui X, Rosner B, Willett WC, et al.Dietary fat, fiber, and carbohydrate intake in relation to risk of endometrial cancer[J]. Cancer Epidemiol Biomarkers Prev,2011,20(5):978-989.
[21] Shu XO, Zheng W, Potischman N, et al.A population-based case-control study of dietary factors and endometrial cancer in Shanghai, People's Republic of China[J]. Am J Epidemiol,1993,137(2):155-165.
[22] Goodman MT, Hankin JH, Wilkens LR, et al.Diet, body size, physical activity, and the risk of endometrial cancer[J]. Cancer Res,1997,57(22):5077-5085.
[23] Goodman MT, Wilkens LR, Hankin JH, et al.Association of soy and fiber consumption with the risk of endometrial cancer[J]. Am J Epidemiol,1997,146(4):294-306.
[24] Jain MG, Howe GR, Rohan TE, et al.Nutritional factors and endometrial cancer in Ontario, Canada[J]. Cancer Control,2000,7(3):288-296.
[25] Littman AJ, Beresford SA, White E, et al.The association of dietary fat and plant foods with endometrial cancer (United States)[J]. Cancer Causes Control,2001,12(8):691-702.
[26] Xu WH, Dai Q, Xiang YB, et al.Nutritional factors in relation to endometrial cancer: a report from a population-based case-control study in Shanghai, China[J]. Int J Cancer,2007,120(8):1776-1781.
[27] Lucenteforte E, Talamini R, Montella M, et al.Macronutrients, fatty acids and cholesterol intake and endometrial cancer[J]. Ann Oncol,2008,19(1):168-172.
[28] Chandran U, Bandera EV, Williams-King MG, et al.Adherence to the dietary guidelines for Americans and endometrial cancer risk[J]. Cancer Causes Control,2010, 21(11):1895-1904.
[29] Biel RK, Csizmadi I, Cook LS, et al.Risk of endometrial cancer in relation to individual nutrients from diet and supplements[J]. Public Health Nutr,2011,14(11):1948-1960.
[30] Salazar-Martinez E, Lazcano-Ponce E, Sanchez-Zamorano LM, et al.Dietary factors and endometrial cancer risk. Results of a case-control study in Mexico[J]. Int J Gynecol Cancer,2005, 15(5):938-945.
[31] Yeh M, Moysich KB, Jayaprakash V, et al.Higher intakes of vegetables and vegetable-related nutrients are associated with lower endometrial cancer risks[J]. J Nutr,2009,139(2):317-322.
[32] Furberg AS, Thune I.Metabolic abnormalities (hypertension, hyperglycemia and overweight), lifestyle (high energy intake and physical inactivity) and endometrial cancer risk in a Norwegian cohort[J]. Int J Cancer,2003, 104(6):669-676.
[33] Aubertin-Leheudre M, Gorbach S, Woods M, et al.Fat/fiber intakes and sex hormones in healthy premenopausal women in USA[J]. J Steroid Biochem Mol Biol,2008, 112(1-3):32-39.
[34] Michels KB, Mohllajee AP, Roset-Bahmanyar E, et al.Diet and breast cancer: a review of the prospective observational studies[J]. Cancer,2007,109(12 Suppl):2712-2749.
[35] Wu AH, Stram DO, Pike MC.RESPONSE: Re: Meta-analysis: Dietary Fat Intake, Serum Estrogen Leve-ls, and the Risk of Breast Cancer[J]. J Natl Cancer Inst,1999,91(17):1512.
[36] Akhmedkhanov A, Zeleniuch-Jacquotte A, Toniolo P, et al.Role of exogenous and endogenous hormones in endometrial cancer: review of the evidence and research perspectives[J]. Ann N Y Acad Sci,2001,943:296-315.
[37] Datta SP, Grzybowski AK, Tate SS, et al.Metal-catalysed decomposition of alpha-hydroxypolycarboxylic acids[J]. Nature,1965,207(5001):1047-1049.
[38] Bandera EV, Kushi LH, Moore DF, et al.Dietary lipids and endometrial cancer: the current epidemiologic evidence[J]. Cancer Causes Control,2007,18(7):687-703.
[39] Wu QJ, Gong TT, Wang YZ, et al.Dietary fatty acids intake and endometrial cancer risk: a dose-response meta-analysis of epidemiological studies[J]. Oncotarget,2015, 6(34):36081-36097.
[40] Piller NB.A comparison of the effectiveness of some anti-inflammatory drugs on thermal oedema[J]. Br J Exp Pathol,1975,56(6):554-560.
[41] Riccardi G, Giacco R, Rivellese AA, et al.Dietary fat, insulin sensitivity and the metabolic syndrome[J]. Clin Nutr,2004,23(4):447-456.
[42] 唐乔乔, 宋红林, 张洁清. 子宫内膜癌与胰岛素抵抗的研究进展[J]. 中国癌症防治杂志,2014,6(1):86-89.
[43] 杨宝华, 艾志宏. 子宫内膜癌的筛查现状[J]. 诊断学理论与实践,2016,15(2):202-204.
Options
Outlines

/

〈 〉