Dietary fat and risk of endometrial cancer: A meta-analysis

doi:10.16150/j.1671-2870.2016.06.010

Abstract

Abstract: Objective: To evaluate the relationship between dietary fat and risk of endometrial cancer (EC). Methods: This meta-analysis was a systematic review of literature published up to June, 2016. Data from PubMed, Web of Science, EMbase, CBM, VIP, and WanFang Data were retrieved and analyzed the relationship between dietary fat and risk of endometrial cancer. All literatures retrieved were screened and extracted according to the inclusion and exclusion criteria by two researchers independently using Stata 11.0 software. The meta-analysis was performed by study design of fat types (total fat, saturated fat, monounsaturated fat and polyunsaturated fat). Results: A total of 15 studies involving 6 480 participants were included. Compared with low intake of fat, high intake of total fat, saturated fat led to a higher risk of endometrial cancer [OR=1.22, 95%CI: 1.02-1.46; OR=1.21, 95%CI: 1.00-1.41]. According to subgroup analysis, the OR for case-control studies were 1.39 (95%CI: 1.14-1.70) in total fat and 1.34 (95%CI: 1.13-1.60) in saturated fat. The summarized RR based on cohort studies was 0.80(0.65-0.98) for total fat. Positive correlation between dietary saturated fat intake and risk of endometrial cancer was observed in studies in United States (OR=1.39, 95%CI: 1.00-1.93), also with high total energy intake（OR=2.17, 95%CI: 1.57-2.99) and smokers(OR=1.30, 95%CI: 1.04-1.62). Conclusions: The meta-analysis of case-control studies reveal that high intake of total fat and saturated fat increase the risk of endometrial cancer. The results of subtype analysis also indicate that high saturated fat intake might increase the risk of endometrial cancer in smoking and high energy intake group. Additional experimental and epidemiological studies with larger participants worldwide are necessary to validate the association between fat intake and risk of endometrial cancer.

Key words: Fat, Endometrial cancer, Literature review, Meta-analysis

CLC Number:

R737.33

WANG Jin, WANG Songtao, LIU Xiaoyang, HONG Yongzhi, ZHAO Peng. Dietary fat and risk of endometrial cancer: A meta-analysis[J]. Journal of Diagnostics Concepts & Practice, 2016, 15(06): 595-601.

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