Journal of Diagnostics Concepts & Practice >

2022 , Vol. 21 >Issue 03: 385 - 389

DOI: https://doi.org/10.16150/j.1671-2870.2022.03.016

Original articles

Study on blood oxygen level-dependent magnetic resonance imaging for the assessment of early renal hypoxia in chronic kidney disease

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  • a. Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
    b. Department of Nephrology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China

Received date: 2022-06-13

  Online published: 2022-08-17

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Abstract

Objective: To evaluate value of blood oxygen level-dependent (BOLD) magnetic resonance imaging (MRI) for early renal hypoxia assessment in chronic kidney disease(CKD). Methods: Fifty-two patients with CKD and 52 age- and sex-matched health volunteers underwent BOLD MRI of the kidneys. Serum creatinine (sCr) levels and estimated GFR (eGFR) were collected. The patients were classified into 5 stages according to the National Kidney Foundation′s Kidney Disease Outcomes Quality Initiative. Difference in R2*s were compared between patients and volunteers and among different stages of CKD. Results: In patients with CKD and volunteers, R2* of renal medulla was higher than that of renal cortex (P<0.05). Compared with those of volunteers, medulla R2*s in patients with CKD were significantly lower [(16.40 ± 2.47)/s vs (18.17± 2.38)/s, P<0.05]. There were no differences in cortical R2*s among CKD stages and volunteers (P>0.05). However, medullar R2*s were lower in patients with CKD1 [(16.55 ± 2.12)/s], CKD4 [(16.48 ± 2.95)/s], or CKD5 [(13.99 ± 2.21)/s] than those in volunteers [(18.17± 2.38)/s] (P<0.05). Conclusions: BOLD MRI is sensitive to renal medullary hypoxia, and which is helpful for diagnosing early stage of CKD.

Key words： Chronic kidney disease; Blood oxygen level-dependent magnetic resonance imaging; Hypoxia

Cite this article

HUANG Juan, ZHU Xiaolei, LI Xiao, CHEN Kemin, YAN Fuhua, XU Xueqin . Study on blood oxygen level-dependent magnetic resonance imaging for the assessment of early renal hypoxia in chronic kidney disease[J]. Journal of Diagnostics Concepts & Practice, 2022 , 21(03) : 385 -389 . DOI: 10.16150/j.1671-2870.2022.03.016

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