Study on blood oxygen level-dependent magnetic resonance imaging for the assessment of early renal hypoxia in chronic kidney disease

doi:10.16150/j.1671-2870.2022.03.016

Abstract

Abstract:

Objective: To evaluate value of blood oxygen level-dependent (BOLD) magnetic resonance imaging (MRI) for early renal hypoxia assessment in chronic kidney disease(CKD). Methods: Fifty-two patients with CKD and 52 age- and sex-matched health volunteers underwent BOLD MRI of the kidneys. Serum creatinine (sCr) levels and estimated GFR (eGFR) were collected. The patients were classified into 5 stages according to the National Kidney Foundation′s Kidney Disease Outcomes Quality Initiative. Difference in R2*s were compared between patients and volunteers and among different stages of CKD. Results: In patients with CKD and volunteers, R2* of renal medulla was higher than that of renal cortex (P<0.05). Compared with those of volunteers, medulla R2*s in patients with CKD were significantly lower [(16.40 ± 2.47)/s vs (18.17± 2.38)/s, P<0.05]. There were no differences in cortical R2*s among CKD stages and volunteers (P>0.05). However, medullar R2*s were lower in patients with CKD1 [(16.55 ± 2.12)/s], CKD4 [(16.48 ± 2.95)/s], or CKD5 [(13.99 ± 2.21)/s] than those in volunteers [(18.17± 2.38)/s] (P<0.05). Conclusions: BOLD MRI is sensitive to renal medullary hypoxia, and which is helpful for diagnosing early stage of CKD.

Key words: Chronic kidney disease, Blood oxygen level-dependent magnetic resonance imaging, Hypoxia

CLC Number:

R692

HUANG Juan, ZHU Xiaolei, LI Xiao, CHEN Kemin, YAN Fuhua, XU Xueqin. Study on blood oxygen level-dependent magnetic resonance imaging for the assessment of early renal hypoxia in chronic kidney disease[J]. Journal of Diagnostics Concepts & Practice, 2022, 21(03): 385-389.

Figures/Tables 4

References 24

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R2*值	对照组			CKD组
R2*值	左肾	右肾	P值	左肾	右肾	P值
肾皮质	12.60±1.47	12.77±1.09	0.501	12.67±2.27	13.07±2.14	0.363
肾髓质	18.31±2.88	17.96±2.45	0.509	16.21±2.42	16.59±3.00	0.466

分组	肾皮质R2*值	肾髓质R2*值	P值
对照组（n=52）	12.69±1.09	18.17±2.38	<0.001
CKD组（n=52）	12.91±2.06	16.40±2.47	<0.001
CKD 1期（n=13）	12.47±1.57	16.55±2.12	<0.001
CKD 2期（n=11）	12.89±2.30	17.38±2.51	<0.001
CKD 3期（n=10）	13.80±2.67	16.91±1.78	0.001
CKD 4期（n=9）	13.37±1.69	16.48±2.95	0.017
CKD 5期（n=9）	12.81±2.66	13.99±2.21	0.354

指标	肾皮质R2*值		肾髓质R2*值
指标	r值	P值	r值	P值
eGFR	-0.120	0.413	0.151	0.312
sCr	0.227	0.117	-0.268	0.069