Objective: To investigate the incidence of stomach cancer in 2016 and the trend of incidence during 2002-2016 in Shanghai. Methods: The data on new-diagnosed stomach cancer during 2002-2016 were obtained from population-based cancer registry in Shanghai Municipal Center for Disease Control and Prevention. The incidence of stomach cancer stratified by year of diagnosis, gender, and age-group were analyzed. The number, proportion, crude rate, age-specific rate, age-standardized and annual percentage change were calculated, and the trends of incidence were evaluated. Segi′s World Standard Population in 1960 was used to calculate age-standardized rates of incidence and mortality, and the Joinpoint was used to analyze the trend of incidence of stomach cancer. Results: The new stomach cancer cases in Shanghai were 5 979 in 2016. The crude rate of incidence was 41.29/105 and the age-standardized rate was 15.85/105. The stomach cancer was one the most common cancers and ranked fourth in Shanghai. The age-standardized rate in male (21.19/105) was higher than that in female (10.84/105). The age-standardized rate of stomach cancer decreased during 2002-2016 in both male and female, and the APC was -2.93% (-3.23%, -2.63%) in male and -2.70% (-2.98%, -2.42%) in female, respectively. The morbidity rates of stomach cancer increased with age, which was <10/105 before 45 years, 17.08/105 in male and 13.22/105 in female between 45 and 49 years. After 50 years, the rates increased markedly and reached peak in age group of 80-84 years. While the age-specific incidence rates in all age groups showed decreased trend during 2002 through 2016, especially in the younger age group(<50 years). Conclusions: Population-based incidence data can provide helpful information in prevention of stomach cancer and policy decision.