Analysis on incidence of stomach cancer in 2016 and trend of incidence during 2002-2016 in Shanghai

doi:10.16150/j.1671-2870.2022.04.008

Abstract

Abstract:

Objective: To investigate the incidence of stomach cancer in 2016 and the trend of incidence during 2002-2016 in Shanghai. Methods: The data on new-diagnosed stomach cancer during 2002-2016 were obtained from population-based cancer registry in Shanghai Municipal Center for Disease Control and Prevention. The incidence of stomach cancer stratified by year of diagnosis, gender, and age-group were analyzed. The number, proportion, crude rate, age-specific rate, age-standardized and annual percentage change were calculated, and the trends of incidence were evaluated. Segi′s World Standard Population in 1960 was used to calculate age-standardized rates of incidence and mortality, and the Joinpoint was used to analyze the trend of incidence of stomach cancer. Results: The new stomach cancer cases in Shanghai were 5 979 in 2016. The crude rate of incidence was 41.29/105 and the age-standardized rate was 15.85/105. The stomach cancer was one the most common cancers and ranked fourth in Shanghai. The age-standardized rate in male (21.19/105) was higher than that in female (10.84/105). The age-standardized rate of stomach cancer decreased during 2002-2016 in both male and female, and the APC was -2.93% (-3.23%, -2.63%) in male and -2.70% (-2.98%, -2.42%) in female, respectively. The morbidity rates of stomach cancer increased with age, which was <10/105 before 45 years, 17.08/105 in male and 13.22/105 in female between 45 and 49 years. After 50 years, the rates increased markedly and reached peak in age group of 80-84 years. While the age-specific incidence rates in all age groups showed decreased trend during 2002 through 2016, especially in the younger age group(<50 years). Conclusions: Population-based incidence data can provide helpful information in prevention of stomach cancer and policy decision.

Key words: Stomach Cancer, Incidence, Epidemiology, Time trend, Shanghai

CLC Number:

R541.7

BAO Pingping, WU Chunxiao, GU Kai, PANG Yi, WANG Chunfang, SHI Liang, XIANG Yongmei, GONG Yangming, DOU Jianming, WU Mengyin, FU Chen, SHI Yan. Analysis on incidence of stomach cancer in 2016 and trend of incidence during 2002-2016 in Shanghai[J]. Journal of Diagnostics Concepts & Practice, 2022, 21(04): 462-469.

Figures/Tables 6

References 25

[1]	Sung H, Ferlay J, Siegel RL, et al. Global cancer statistics 2020: globocan estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J]. CA Cancer J Clin, 2021, 71(3):209-249. doi: 10.3322/caac.21660 URL
[2]	王少明, 郑荣寿, 张思维, 等. 2015年中国胃癌流行特征分析[J]. 中华流行病学杂志, 2019, 40(12):1517-1521. pmid: 32062908
	Wang SM, Zheng RS, Zhang SW, et al. Epidemiological characteristics of gastric cancer in China, 2015[J]. Chin J Epidemiol, 2019, 40(12):1517-1521. doi: 10.3760/cma.j.issn.0254-6450.2019.12.003 pmid: 32062908
[3]	周家琛, 郑荣寿, 庄贵华, 等. 2000—2015年中国肿瘤登记地区胃癌发病趋势及年龄变化[J]. 实用肿瘤学杂志, 2020, 34(1):1-5.
	Zhou JC, Zheng RS, Zhuang GH, et al. Analysis on the trend of gastric cancer incidence and age change in cancer registration regions of China,2000 to 2015[J]. Pract Oncol J, 2020, 34(1):1-5.
[4]	Zhang X, Li M, Chen S, et al. Endoscopic screening in Asian countries is associated with reduced gastric cancer mortality: a meta-analysis and systematic review[J]. Gastroenterology, 2018, 155(2):347-354. doi: S0016-5085(18)30487-6 pmid: 29723507
[5]	朱娟, 王少明, 陈茹, 等. 胃癌筛查现状的研究进展[J]. 中华肿瘤杂志, 2020, 42(7):603-608. pmid: 32842452
	Zhu J, Wang SM, Chen R, et al. Progress on screening for gastric cancer[J]. Chin J Oncol, 2020, 42(7):603-608. doi: 10.3760/cma.j.cn112152-20191125-00759 pmid: 32842452
[6]	上海市疾病预防控制中心. 上海市恶性肿瘤发病率、死亡率和生存率(2001- 2012)[M]. 上海: 上海科学普及出版社, 2017:1-6.
	Shanghai Municipal Center For Disease Control & Prevention. Incidence rate, mortality and survival rate of malignant tumors in Shanghai (2001- 2012)[M]. Shanghai: Shanghai Science Popularization press, 2017:1-6.
[7]	全国肿瘤防治研究办公室, 卫生部卫生统计信息中心, 全国肿瘤登记中心. 中国肿瘤登记工作指导手册[M]. 北京: 中国协和医科大学出版社, 2004.
	National Cancer Prevention and Treatment Research Office, Health Statistics Information Center of the Ministry of Health, National Cancer Registration Center. Guidelines for cancer registration in China[M]. Beijing: China Union Medical College Press, 2004.
[8]	Parkin DM, Chen VW, Ferlay J, et al. Comparability and Quality Control in Cancer Registration. IARC Technical Report No 19[M]. Lyon: IARC Press, 1994.
[9]	Bosman FT, Carneiro F, Hruban RH, et al. WHO Classification of Tumours of the Digestive System, 4th Ed, Volume 3[M]. Lyon: IARC Press, 2010.
[10]	Segi M. Cancer mortality for selected sites in 24 countries (1950—1957)[M]. Sendai,Japan: Tohoku University School of Medicine, 1960.
[11]	Joinpoint Regression Program, Version 4.8.0.1.April, 2020; Statistical Research and Applications Branch, National Cancer Institute.
[12]	Kim HJ, Fay MP, Feuer EJ, et al. Permutation tests for joinpoint regression with applications to cancer rates[J]. Stat Med, 2000, 19(3):335-351. doi: 10.1002/(sici)1097-0258(20000215)19:3<335::aid-sim336>3.0.co;2-z pmid: 10649300
[13]	吴春晓, 顾凯, 庞怡, 等. 2016年上海市恶性肿瘤发病和死亡情况与2002—2016年的变化趋势分析[J]. 中国癌症杂志, 2021, 31(10):879-891.
	Wu CX, Gu K, Pang Y, et al. Analysis of the current status of cancer incidence and mortality in Shanghai, 2016 and trends of 2002—2016[J]. China Oncol, 2021, 31(10):879-891.
[14]	Ferlay J, Ervik M, Lam F, et al. Global Cancer Observatory: Cancer Today[DB/OL]. Lyon, France: International Agency for Research on Cancer. [2022-01-15]. https://gco.iarc.fr/today,accessed.
[15]	汪荃, 韩仁强, 李莹, 等. 2015年江苏省胃癌流行现状及趋势分析[J]. 中国肿瘤, 2019, 28(11):838-844.
	Wang Q, Han RQ, Li Y, et al. Incidence, mortality and trend of stomach cancer in Jiangsu Province[J]. China Cancer, 2019, 28(11):838-844.
[16]	许欢, 李科, 梁颖茹, 等. 2004-2016年广州市胃癌流行情况及发病趋势[J]. 中华肿瘤防治杂志, 2020, 27(11):835-839.
	Xu H, Li K, Liang YR, et al. Epidemiology and incidence trends of stomach cancer in Guangzhou, 2004-2016[J]. Chin J Cancer Prev & Treat, 2020, 27(11):835-839.
[17]	邹文斌, 吴浩, 蔡全才, 等. 胃癌危险因素研究进展[J]. 中国实用内科杂志, 2014, 34(4):415-420.
	Zou WB, Wu H, Cai QC, et al. Research advance onrisk factors of gastric cancer[J]. Chin J Pract Intern Med, 2014, 34(4):415-420.
[18]	Tanaka M, Ma E, Tanaka H, et al. Trends of stomach cancer mortality in Eastern Asia in 1950-2004: comparative study of Japan, Hong Kong and Singapore using age, period and cohort analysis[J]. Int J Cancer, 2012, 130(4):930-936. doi: 10.1002/ijc.26080 pmid: 21425256
[19]	Arnold M, Park JY, Camargo MC, et al. Is gastric cancer becoming a rare disease? A global assessment of predicted incidence trends to 2035[J]. Gut, 2020, 69(5):823-829. doi: 10.1136/gutjnl-2019-320234 pmid: 32001553
[20]	Kwong MF, Nick T, Paul M, 等. 胃癌预防亚太地区共识指南[J]. 胃肠病学, 2008, 13(4):231-240.
	Kwong MF, Nick T, Paul M, et al. Asia-Pacific consensus guidelines on gastric cancer prevention[J]. Chin J Gastroenterol, 2008, 13(4):231-240.
[21]	Sugimoto M, Murata M, Yamaoka Y. Chemoprevention of gastric cancer development after Helicobacter pylori eradication therapy in an East Asian population: Meta-analysis[J]. World J Gastroenterol, 2020, 26(15):1820-1840. doi: 10.3748/wjg.v26.i15.1820 URL
[22]	Hamashima C. Systematic review group and guideline development group for gastric cancer screening guidelines: update version of the Japanese guidelines for gastric cancer screening[J]. Jpn J Clin Oncol, 2018, 48(7):673-683. doi: 10.1093/jjco/hyy077 pmid: 29889263
[23]	Park HA, Nam SY, Lee SK, et al. The Korean guideline for gastric cancer screening[J]. J Korean Med Assoc, 2015, 58(5):373-384. doi: 10.5124/jkma.2015.58.5.373 URL
[24]	冯海静, 郎爽, 杨志超, 等. 互联网+外卖食品的安全问题[J]. 食品安全质量检测学报, 2018, 9(16):4218-4222.
	Feng HJ, Lang S, Yang ZC, et al. Safety problem of take-out food under internet plus[J]. J Food Saf & Qual, 2018, 9(16):4218-4222.
[25]	苏凡, 张思, 蒋报文, 等. 江西省某高校大学生外卖行为对超重肥胖的影响[J]. 中国学校卫生, 2021, 42(1):124-127,131.
	Su F, Zhang S, Jiang BW, et al. Effects of takeout food consumption on overweight and obesity among college students in Jiangxi Province[J]. Chin J Sch Health, 2021, 42(1):124-127,131.

性别	例数（n）	构成比（%）	粗率/10万	标化率/10万	截缩率/10万	累积率%			顺位
性别	例数（n）	构成比（%）	粗率/10万	标化率/10万	35~64岁	0~64岁	0~74岁	0~84岁	顺位
合计	5 979	8.03	41.29	15.85	23.41	0.84	1.83	3.53	4
男性	3 933	10.12	54.75	21.19	29.54	1.06	2.50	4.91	3
女性	2 046	5.75	28.04	10.84	17.33	0.62	1.16	2.28	5

年龄分组	年份	男		女
年龄分组	年份	APC（%）	95%CI	APC（%）	95%CI
30~34岁	2002-2016	-3.82	-1.79,0.81	-0.11	-2.64,2.49
35~39岁	2002-2016	-3.83^*	-6.82,-0.74	-2.72^*	-4.80,-0.59
40~44岁	2002-2016	-5.43^*	-6.44,-4.42	-2.26^*	-4.10,-0.39
45~49岁	2002-2016	-4.85^*	-6.17,-3.51	-3.42^*	-4.65,-2.17
50~54岁	2002-2016	-2.74^*	-3.89,-1.57	-1.57^*	-3.04,-0.08
	2002-2007	-2.87^*	-5.55,-0.11
	2007-2012	1.03	-2.90,5.11
	2012-2016	-10.53^*	-14.00,-6.91
55~59岁	2002-2016	-1.69^*	-2.52,-0.86	-1.36^*	-2.44,-0.26
60~64岁	2002-2016	-2.16^*	-2.97,-1.34	-3.00^*	-4.30,-1.69
65~69岁	2002-2016	-2.54^*	-3.23,-1.85	-3.71^*	-4.39,-3.03
70~74岁	2002-2016	-3.58^*	-4.08,-3.08	-3.96^*	-4.88,-3.03
75~79岁	2002-2016	-3.27^*	-3.81,-2.73	-3.16^*	-3.81,-2.51
	2002-2006	-6.03^*	-8.78,-3.20
	2006-2016	-2.51^*	-3.21,-1.79
80~84岁		-3.55^*	-4.05,-3.05	-2.86^*	-3.89,-1.81
≥85岁		-2.86^*	-3.68,-2.03	-1.47^*	-2.17,-0.77
合计^**		-2.93^*	-3.23,-2.63	-2.70^*	-2.98,-2.42

分类	2002年至2006年		2007年至2011年		2012年至2016年
分类	例数（n）	构成比（%）	例数（n）	构成比（%）	例数（n）	构成比（%）
诊断亚部位（ICD-10编码与名称）
贲门 C16.0	3 257	11.60	2 673	9.12	2 110	7.07
胃底 C16.1	393	1.40	480	1.64	473	1.58
胃体 C16.2	2 215	7.89	2 592	8.85	2 174	7.28
胃窦 C16.3	6 158	21.94	6 272	21.40	5 361	17.96
幽门 C16.4	262	0.93	166	0.57	133	0.45
胃小弯 C16.5	2 002	7.13	2 528	8.63	2 027	6.79
胃大弯 C16.6	150	0.53	100	0.34	74	0.25
胃交搭跨越 C16.8	786	2.80	661	2.26	697	2.34
胃NOS C16.9	12 844	45.76	13 830	47.20	16 794	56.27
病理组织学类型
鳞癌	187	0.67	190	0.65	134	0.45
管状和乳头状腺癌	1 402	4.99	1 443	4.93	1 141	3.82
黏液腺癌	810	2.89	829	2.83	658	2.20
印戒细胞癌	1 930	6.88	2 339	7.98	2 385	7.99
类癌	44	0.16	38	0.13	16	0.05
神经内分泌癌	17	0.06	64	0.22	142	0.48
其他和未分型腺癌	14 324	51.04	15 968	54.49	15 915	53.33
腺鳞癌	37	0.13	26	0.09	27	0.09
胃肠道间质肉瘤	422	1.50	691	2.36	821	2.75
其他和未分型	8 894	31.69	7 714	26.33	8 604	28.83
诊断时分期
Ⅰ期	1 508	5.37	1 915	6.54	2 194	7.35
Ⅱ期	2 466	8.79	2 453	8.37	2 074	6.95
Ⅲ期	3 242	11.55	3 578	12.21	3 221	10.79
Ⅳ期	3 989	14.21	4 769	16.28	4 440	14.88
不详	16 862	60.08	16 587	56.61	17 914	60.03