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Paradrenal anastomosing hemangioma: a case report with literature review
Received date: 2021-06-09
Online published: 2023-04-23
Objective: This paper reported 1 case of paradrenal anastomosing hemangioma (AH), and to summarize the clinicopathological features, diagnosis and differential diagnosis of AH. Methods: The clinical data of this patient was collected, the histological morphology and immunohistochemical characteristics were observed and analyzed in combination with relevant literature. Results: The tumor was located in the adipose tissue around the adrenal gland, it was well circumscribed, gray and red colored. Microscopically, the tumor was composed of irregularly anastomosing sinusoidal-like spaces lined by hobnail endothelial cells, focal mild atypia was observed. Intravascular fibrin thrombi and hyaline globules could be seen. Immunohistochemical results showed diffuse staining for endothelial markers, including CD31 and CD34. D2-40, CK5/6, calretinin, CKpan, EMA, Melan-A and HMB45 immunostains were negative. Ki-67 staining indicated a low proliferative activity. Eventually this patient was diagnosed with AH. Conclusions: AH is a rare but distinct type of vascular neoplasm. Owing to its striking anastomosing appearance, it needs to be distinguished from well differentiated angiosarcoma. In addition, the differential diagnosis of urogenital AH also includes angiomyolipoma, adenomatoid tumor, and hemangiomatoid hyperplasia secondary to renal cell carcinoma.
YAN Huaru, LIU Kun, HAN Zhihong, FANG Zhen, WU Lili . Paradrenal anastomosing hemangioma: a case report with literature review[J]. Journal of Diagnostics Concepts & Practice, 2022 , 21(06) : 735 -740 . DOI: 10.16150/j.1671-2870.2022.06.12
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