Journal of Diagnostics Concepts & Practice >

2023 , Vol. 22 >Issue 03: 292 - 299

DOI: https://doi.org/10.16150/j.1671-2870.2023.03.13

Original articles

Clinicopathological features of urothelial carcinoma

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  • 1a. Department of Pathology, 1b. Department of Internal Medicine-Oncology, Nanjing Jinling Hospital, Nanjing University School of Medicine, Jiangsu Nanjing 210002, China
    2. Department of Pathology, Affiliated Drum Tower Hospital, Medical School of Jiangsu Nanjing University, Nanjing 210008, China

Received date: 2023-02-14

  Online published: 2023-11-17

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Abstract

Objective: This paper aims to investigate the clinicopathological features of bladder cancer (UBUC) and upper urinary tract cancer (UTUC). Methods: A total of 115 patients with urothelial carcinoma (UC) admitted to Jinling Hospital and Nanjing Drum Tower Hospital from May 2017 to February 2020 were randomly selected and retrospectively analyzed, including 80 cases of UBUC and 35 cases of UTUC. The differences in clinicopathological characteristics between the two groups were analyzed by chi-square test and Fisher’s exact test. Kaplan-Meier method and Log-rank test were used for survival analysis, and Cox proportional hazards model was used for multivariate analysis. Results: Female patients were more common in UTUC (28.6% vs. 10.0%, P=0.012). UBUC was more likely to have neural invasion (33.7% vs.5.7%, P=0.002), vascular invasion (45.0% vs. 20.0%, P=0.011), and carcinoma in situ (23.7% vs. 2.9%, P=0.007). The main histological variants of UBUC were micropapillary differentiation (31.3%), squamous differentiation (25.0%) and adenoid differentiation (12.6%), while poorly differentiated carcinoma (33.3%), sarcomatoid differentiation (22.2%) and neuroendocrine differentiation (22.2%) were more common in UTUC. Survival analysis showed that there was no significant difference in overall survival (OS) between UTUC and UBUC (P>0.05). Neural invasion, vascular invasion, clinical stage, and lymph node metastasis are associated with OS in UC, and vascular invasion and neural invasion are independent predictors of overall survival in UC. Conclusions: Compared with UBUC, the incidence of UTUC in women is significantly higher than that in men, while UBUC is more likely to have neural invasion, vascular invasion and carcinoma in situ. Histological variants of UBUC are micropapillary, squamous and adenoid, while UTUC is mostly poorly differentiated carcinoma, sarcomatoid and neuroendocrine differentiation. There is no significant difference in prognosis between the two groups. Vascular invasion and neural invasion are significant predictors of UC-OS.

Key words： Urothelial carcinoma; Upper urinary tract cancer; Bladder cancer; Clinical pathology; Prognosis

Cite this article

ZHOU Xiaodie, CHEN Weiwei, YU Bo, WANG Xuan, WANG Jianjun, SHI Qunli, RAO Qiu, BAO Wei . Clinicopathological features of urothelial carcinoma[J]. Journal of Diagnostics Concepts & Practice, 2023 , 22(03) : 292 -299 . DOI: 10.16150/j.1671-2870.2023.03.13

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