Objective: To analyze the death characteristics of residents in Shannan City, Tibet autonomous region in 2021 for understanding the causes of death and the sequence of causes of death, and provide a basis for formulating re-levant prevention and control strategies. Methods: Indicators of mortality rate, standardized mortality rate, years of life lost (YLL), probability of premature death, and life expectancy to reflect causes of death were analyzed in Shannan City in 2021. Results: In 2021, the total mortality rate of residents in Shannan City was 500.3/100 000 (standardized rate 1060.9/100,000); the male mortality rate was 539.2/100 000 (standardized rate 1 282.5/100, 000); the female mortality rate was 462.5/100 000 (standardized rate 889.5/100 000). The mortality rate of males was higher than that of females. The total mortality YLL was 35 998.8, among which there was 20 827.0 for males and 15171.8 for females. The top five causes of death among residents were cerebrovascular disease, heart disease, malignant tumor, respiratory system disease, and infectious disease, accounting for 71.7% of the reported deaths. Chronic non-communicable diseases accounted for 68.4% of all deaths. The probability of premature death from the four main chronic diseases was 17.5%, among which there was 21.9% for men and 13.5% for women. The life expectancy of residents in Shannan was 75.3 years, 72.9 years for men and 77.7 years for women. Conclusions: The probability of premature death among Shannan city residents for four major categories of chronic diseases is higher than the national level, and the four major categories of chronic diseases are still the main causes of death in Shannan City residents. Reducing premature death and YLL from chronic diseases is the main goal of preventing and controlling chronic diseases.