高尿酸血症与心血管疾病关系的研究进展

doi:10.16138/j.1673-6087.2025.04.14

摘要/Abstract

摘要：

高尿酸血症是一种嘌呤代谢异常所引起的疾病，我国患病率逐年升高。尿酸升高不仅可导致痛风发作，还与多种心血管疾病发生发展密切相关。高尿酸血症可通过促进炎症反应、引起内皮功能障碍以及过度激活肾素-血管紧张素-醛固酮系统等机制，促进心血管疾病的发生和发展。本文综述了高尿酸血症与冠心病、心房颤动、高血压及心力衰竭等心血管疾病之间的关系。

关键词: 高尿酸血症, 心血管疾病, 冠心病, 心房颤动, 心力衰竭, 高血压

Abstract:

Hyperuricemia is a disease caused by abnormal purine metabolism. The prevalence of hyperuricemia is increasing annually in China. Elevated uric acid levels not only lead to gout attacks but are also associated with the occurrence and development of cardiovascular diseases. Research indicates that hyperuricemia can facilitate the onset and progression of cardiovascular diseases through promoting inflammation, causing endothelial dysfunction, and over activating the renin-angiotensin-aldosterone system. This review discusses the association between hyperuricemia and various cardiovascular diseases, including coronary atherosclerosis, atrial fibrillation, hypertension, and heart failure.

Key words: Hyperuricemia, Cardiovascular disease, Coronary atherosclerotic heart disease, Atrial fibrillation, Heart failure, Hypertension

中图分类号:

R589.3

靳正逸, 刘齐龙, 胡佳琪, 徐霞, 高洁. 高尿酸血症与心血管疾病关系的研究进展[J]. 内科理论与实践, 2025, 20(04): 334-339.

JIN Zhengyi, LIU Qilong, HU Jiaqi, XU Xia, GAO Jie. Advances in understanding the association between hyperuricemia and cardiovascular diseases[J]. Journal of Internal Medicine Concepts & Practice, 2025, 20(04): 334-339.

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