内科理论与实践 ›› 2022, Vol. 17 ›› Issue (06): 453-456.doi: 10.16138/j.1673-6087.2022.06.006
收稿日期:
2022-05-17
出版日期:
2022-12-30
发布日期:
2023-02-27
通讯作者:
朱 颖 E-mail: SUN Chaoa, YAO Weiyanb, TANG Yumingb, HUANG Jiab, ZHU Yingb()
Received:
2022-05-17
Online:
2022-12-30
Published:
2023-02-27
摘要:
目的:探索无症状糜烂性食管炎(asymptomatic erosive esophagitis,AEE)与慢性活动性胃炎之间的关系。方法:采用病例对照研究,选取无胃食管反流相关症状的胃镜体检人群,其中存在内镜下糜烂性食管炎的为AEE组,无内镜下糜烂性食管炎的为对照组。收集2组的人口统计学、胃镜检查结果及胃镜病理进行比较。结果:共纳入胃镜检查体检者1 818名,其中AEE组209例,对照组1 609名。多元Logistic回归分析显示,老年(P=0.008)、高体质量指数(body mass index,BMI)(P<0.001)、食管裂孔疝(P<0.001)与AEE的风险增加有关;而女性(P<0.001)、胆汁反流(P=0.007)及活动性胃炎(P=0.041)与AEE的风险降低有关。结论:慢性活动性胃炎与AEE呈负相关。
中图分类号:
孙超, 姚玮艳, 汤玉茗, 黄佳, 朱颖. 无症状糜烂性食管炎与慢性活动性胃炎相关性分析[J]. 内科理论与实践, 2022, 17(06): 453-456.
SUN Chao, YAO Weiyan, TANG Yuming, HUANG Jia, ZHU Ying. Inverse correlation between asymptomatic erosive esophagitis and chronic active gastritis[J]. Journal of Internal Medicine Concepts & Practice, 2022, 17(06): 453-456.
表1
AEE与对照组的比较[$\bar{x}±s$/n(%)]
临床特征 | 对照组 (n=1 608) | AEE (n=208) | t/χ2 | P |
---|---|---|---|---|
年龄(岁) | 50.69±9.00 | 52.35±8.72 | -2.518 | 0.012 |
女性[n(%)] | 617(38.3) | 32(15.4) | 42.761 | <0.001 |
BMI(kg/m2) | 24.14±0.20 | 23.11±0.13 | 4.725 | <0.001 |
食管裂孔疝[n(%)] | 15(1.0) | 24(11.5) | 93.132 | <0.001 |
Hp感染[n(%)] | 586(36.4) | 53(25.5) | 9.929 | 0.002 |
胆汁反流[n(%)] | 132(8.2) | 7(3.4) | 6.174 | 0.013 |
活动性[n(%)] | 15.444 | <0.001 | ||
(+++) | 3(0.2) | 0(0) | ||
(++) | 11(0.7) | 2(1.0) | ||
(+) | 658(40.9) | 57(27.2) | ||
(-) | 937(58.2) | 150(71.8) | ||
炎症[n(%)] | 0.334 | 0.789 | ||
(+++) | 3(0.2) | 0(0) | ||
(++) | 142(8.8) | 16(7.7) | ||
(+) | 1 463(91.0) | 193(92.3) | ||
萎缩[n(%)] | 1.221 | 0.802 | ||
(+++) | 1(0.1) | 0(0) | ||
(++) | 17(1.1) | 3(1.4) | ||
(+) | 233(14.5) | 29(13.9) | ||
(-) | 1 357(84.4) | 177(84.7) | ||
肠化[n(%)] | 1.653 | 0.653 | ||
(+++) | 3(0.2) | 0(0) | ||
(++) | 35(2.2) | 6(2.9) | ||
(+) | 444(27.6) | 64(30.6) | ||
(-) | 1 127(70.0) | 139(66.5) |
表2
AEE与对照组单因素Logistic分析
变量 | OR | 95% CI | P |
---|---|---|---|
年龄 | 3.436 | 2.331~5.076 | <0.001 |
女性 | 0.979 | 0.963~0.995 | 0.012 |
BMI | 1.236 | 1.037~1.649 | <0.001 |
食管裂孔疝 | 13.786 | 7.105~26.748 | <0.001 |
HP感染 | 0.593 | 0.427~0.823 | 0.002 |
胆汁反流 | 0.388 | 0.179~0.841 | 0.016 |
活动性 | |||
(-) | 参考 | 参考 | 参考 |
(+) | 0.541 | 0.393~0.746 | <0.001 |
(++) | 1.136 | 0.249~5.175 | 0.869 |
(+++) | 0 | - | 1 |
炎症 | |||
(+) | 参考 | 参考 | 参考 |
(++) | 0.854 | 0.499~1.463 | 0.566 |
(+++) | 0 | - | 1 |
萎缩 | |||
(-) | 参考 | 参考 | 参考 |
(+) | 0.954 | 0.629~1.447 | 0.825 |
(++) | 1.353 | 0.393~4.663 | 0.632 |
(+++) | 0 | - | 1 |
肠化 | |||
(-) | 参考 | 参考 | 参考 |
(+) | 1.169 | 0.852~1.603 | 0.333 |
(++) | 1.390 | 0.574~3.364 | 0.465 |
(+++) | 0 | - | 1 |
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