目的： 分析三酰甘油葡萄糖（triglyceride-glucose,TyG）指数与新发脂肪性肝病（fatty liver disease,FLD）之间的相关性,从而为FLD的防治提供依据。方法： 采用回顾性队列研究设计,通过便利抽样选取2018年度在我院体检中心进行健康体检的受试者作为基线观察人群,根据TyG指数四分位数分为Q1、Q2、Q3、Q4四组,随访至2020年度。每年收集1次健康体检资料,最终纳入958名受试者,采用Cox比例风险模型和Spearman相关分析TyG指数与新发FLD的关系。结果： FLD的累积发病率随着TyG指数的增高而升高（P<0.05）。Cox比例风险模型经校正年龄、性别、体质量指数（body mass index,BMI）等因素后,Q2、Q3、Q4组FLD发病风险分别为Q1组的2.107 [95%置信区间（confidence interval,CI）：1.317~3.373]、2.598 （95%CI：1.659~4.069）和3.171倍（95%CI：2.036~4.938）。Spearman相关分析显示TyG指数与发生FLD呈正相关,且相关性最高（r=0.302,P<0.001）。结论： FLD的发病风险随着TyG指数的增加而升高,TyG指数是预测FLD发生的有效指标。

Objective To explore the correlation between triglyceride-glucose(TyG) index and new-onset fatty liver disease(FLD) to provide references for the prevention and treatment of FLD. Methods This retrospective cohort study recruited the subjects received physical examination at the physical examination center of our hospital in 2018 by convenience sampling. The participants were divided into four groups according to the quartiles of TyG index: Q1, Q2, Q3, Q4, and they were followed up each year until 2020. A cohort of 958 subjects were included for final analysis. The Cox proportional-hazards regression model and Spearman correlation were used to analyze the association between the TyG index and new-onset FLD. Results The cumulative incidence of FLD increased along with the increase of TyG (P<0.05). After adjusting for multiple factors such as age, gender and body mass index(BMI) with the Cox proportional-hazards regression model, the incidence of FLD in the Q2, Q3, Q4 groups was 2.107 times [95% confidence interval (CI): 1.317-3.373], 2.598 times (95%CI: 1.659-4.069), 3.171 times(95%CI: 2.036-4.938) higher than that in the Q1 group. The Spearman correlation analysis revealed that the TyG index is highest positively related to the new-onset FLD (r=0.302, P<0.001). Conclusions The risk of FLD increased with the increase of TyG, which could be an effective indicator to predict the incidence of FLD.