目的：探索无症状糜烂性食管炎（asymptomatic erosive esophagitis, AEE）与结直肠息肉的关系。方法：采用病例对照研究,选取无胃食管反流症状且在我院接受胃肠镜联合检查的患者,其中糜烂性食管炎患者为AEE组,无内镜下糜烂性食管炎的患者为对照组。AEE组与对照组按年龄和性别进行1∶3配对。收集2组的人口统计学、胃镜、结肠镜和组织病理学结果进行比较。结果：共纳入1 176例患者,其中AEE组有294例,对照组有882例。与对照组相比,AEE组更容易合并结直肠息肉（P<0.001）,息肉主要分布在左半结肠（P<0.001）,且AEE组更易发生高危腺瘤（P=0.034）。此外,与轻度AEE相比,中重度AEE更容易发生高危腺瘤（P=0.003）和多发息肉（P<0.001）,且息肉主要分布在左半结肠（P=0.038）。结论：AEE患者合并结直肠息肉的比例显著升高,且息肉主要分布在左半结肠,中重度AEE更容易合并高危腺瘤。

Objective To explore the correlation between asymptomatic erosive esophagitis(AEE) and colorectal polyps. Methods In this case-control study, the individuals without gastroesophageal reflux symptoms who underwent esophagogastroduodenoscopy(EGD) and colonoscopy in our hospital for a routine health checkup were included in the study and divided into two groups. The AEE group consisted of the patients with erosive esophagitis and without gastroesophageal reflux symptoms. The control group consisted of age-and gender-matched(1∶3) individuals with neither gastroesophageal reflux symptoms nor endoscopic erosive esophagitis. The results of demographics, gastroscopy, colonoscopy, and histopathology were collected. Results A total of 1 176 patients were included in the study, including 294 cases in AEE group and 882 cases in control group. Compared with the control group, the AEE group was more likely to have colorectal polyps(P<0.001), which were mainly distributed in left colon(P<0.001); and the AEE group was more likely to develop high-risk adenomas(P=0.034). In addition, compared with mild AEE, moderate to severe AEE was more possibly to develop high-risk adenomas (P=0.003) and multiple polyps (P<0.001), and the polyps were mainly distributed in left colon(P=0.038). Conclusions The AEE patients are more likely to have polyps, which are mainly distributed in left colon. The moderate to severe AEE patients are more possibly to have high-risk adenomas.