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甲状腺激素对脓毒症脏器功能维护作用的研究进展

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  • 上海交通大学医学院附属瑞金医院急诊科,上海 200025

收稿日期: 2021-04-27

  网络出版日期: 2022-11-04

基金资助

第二轮《促进市级医院临床技能与临床创新三年行动计划(2020—2022年)》重大临床研究项目(SHDC2020CR1028B);上海市科学技术委员会科研计划项目(18411950900);2017上海市医学领军人才项目

Research progress of thyroid hormone on organ function maintenance in sepsis

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Received date: 2021-04-27

  Online published: 2022-11-04

本文引用格式

周易, 陈影, 陈尔真 . 甲状腺激素对脓毒症脏器功能维护作用的研究进展[J]. 内科理论与实践, 2022 , 17(05) : 408 -412 . DOI: 10.16138/j.1673-6087.2022.05.013

参考文献

[1] Singer M, Deutschman CS, Seymour CW, et al. The third international consensus definitions for sepsis and septic shock (Sepsis-3)[J]. JAMA, 2016, 315(8): 801-810.
[2] Burmann B, Mchowat J, Hiller S, et al. Mutual modulation of MIF and bacterial endotoxin may play an important role in the pathogenesis of sepsis[J]. Shock, 2016, 451(6): 107-113.
[3] Georgescu AM, Banescu C, Azamfirei R, et al. Evaluation of TNF-α genetic polymorphisms as predictors for sepsis susceptibility and progression[J]. BMC Infect Dis, 2020, 20(1): 221.
[4] Samuels JM, Moore HB, Moore EE. Coagulopathy in severe sepsis: interconnectivity of coagulation and the immune system[J]. Surg Infect (Larchmt), 2018, 19(2): 208-215.
[5] Luo B, Yu Z, Li Y. Thyroid hormone disorders and sepsis[J]. Biomed Mater Eng, 2017, 28(s1): S237-S241.
[6] Heming N, Sivanandamoorthy S, Meng P, et al. Immune effects of corticosteroids in sepsis[J]. Front Immunol, 2018, 9: 1736.
[7] Bloise FF, Santos AT, de Brito J, et al. Sepsis impairs thyroid hormone signaling and mitochondrial function in the mouse diaphragm[J]. Thyroid, 2020, 30(7): 1079-1090.
[8] Fliers E, Kalsbeek A, Boelen A. Beyond the fixed setpoint of the hypothalamus-pituitary-thyroid axis[J]. Eur J Endocrinol, 2014, 171(5): 197-208.
[9] de Luca R, Davis PJ, Lin HY, et al. Thyroid hormones interaction with immune response, inflammation and non-thyroidal illness syndrome[J]. Front Cell Dev Biol, 2021, 8: 614030.
[10] Peeters RP, Wouters PJ, Kaptein E, et al. Reduced activation and increased inactivation of thyroid hormone in tissues of critically ill patients[J]. J Clin Endocrinol Metab, 2003, 88(7): 3202-3211.
[11] Ellender T, Benzoni N. Updates in sepsis resuscitation[J]. Emerg Med Clin North Am, 2020, 38(4): 807-818.
[12] van den Berghe G. On the neuroendocrinopathy of critical illness[J]. Am J Respir Crit Care Med, 2016, 194(11): 1337-1348.
[13] Fliers E, Bianco AC, Langouche L, et al. Thyroid function in critically ill patients[J]. Lancet Diabetes Endocrinol, 2015, 3(10): 816-825.
[14] Fliers E, Boelen A. An update on non-thyroidal illness syndrome[J]. J Endocrinol Invest, 2021, 44(8): 1597-1607.
[15] Angelousi AG, Karageorgopoulos DE, Kapaskelis AM, et al. Association between thyroid function tests at baseline and the outcome of patients with sepsis or septic shock[J]. Eur J Endocrinol, 2011, 164(2): 147-155.
[16] Lee S, Farwell AP. Euthyroid sick syndrome[J]. Compr Physiol, 2016, 6(2): 1071-1080.
[17] Das N, Kumar TR. Molecular regulation of follicle-stimulating hormone synthesis, secretion and action[J]. J Mol Endocrinol, 2018, 60(3): R131-R155.
[18] Ojamaa K. Signaling mechanisms in thyroid hormone-induced cardiac hypertrophy[J]. Vascul Pharmacol, 2010, 52(4): 113-119.
[19] Chattergoon NN. Thyroid hormone signaling and consequences for cardiac development[J]. J Endocrinol, 2019, 242(1): T145-T160.
[20] Fattahi F, Ward PA. Complement and sepsis-induced heart dysfunction[J]. Mol Immunol, 2017, 84: 57-64.
[21] Stengl M, Bartak F, Sykora R, et al. Reduced L-type calcium current in ventricular myocytes from pigs with hyperdynamic septic shock[J]. Crit Care Med, 2010, 38(2): 579-587.
[22] Ksenzenko SM, Davidson SB, Saba AA, et al. Effect of triiodothyronine augmentation on rat lung surfactant phospholipids during sepsis[J]. J Appl Physiol(1985), 1997, 82(6): 2020-2027.
[23] Al-Saiedy M, Pratt R, Lai P, et al. Dysfunction of pulmonary surfactant mediated by phospholipid oxidation is cholesterol-dependent[J]. Biochim Biophys Acta Gen Subj, 2018, 1862(4): 1040-1049.
[24] Sungurlu S, Kuppy J, Balk RA. Role of antithrombin Ⅲ and tissue factor pathway in the pathogenesis of sepsis[J]. Crit Care Clin, 2020, 36(2): 255-265.
[25] Ali S, Majid S, Niamat Ali M, et al. Evaluation of etiology and pregnancy outcome in recurrent miscarriage patients[J]. Saudi J Biol Sci, 2020, 27(10): 2809-2817.
[26] Fernández V, Videla LA. On the mechanism of thyroid hormone-induced respiratory burst activity in rat polymorphonuclear leukocytes[J]. Free Radic Biol Med, 1995, 19(3): 359-363.
[27] Radman M, Portman MA. Thyroid hormone in the pediatric intensive care unit[J]. J Pediatr Intensive Care, 2016, 5(4): 154-161.
[28] Alamino VA, Montesinos MM, Rabinovich GA, et al. The thyroid hormone triiodothyronine reinvigorates dendritic cells and potentiates anti-tumor immunity[J]. Oncoimmunology, 2016, 5(1): e1064579.
[29] Yildizdaş D, Onenli-Mungan N, Yapicioğlu H, et al. Thyroid hormone levels and their relationship to survival in children with bacterial sepsis and septic shock[J]. J Pediatr Endocrinol Metab, 2004, 17(10): 1435-1442.
[30] Lado-Abeal J. Non-thyroidal illness syndrome, the hidden player in the septic shock induced myocardial contractile depression[J]. Med Hypotheses, 2020, 142: 109775.
[31] Kim JG, Shin H, Kim W, et al. The value of decreased thyroid hormone for predicting mortality in adult septic patients[J]. Sci Rep, 2018, 8(1): 14137.
[32] Liu YC, Jiang TY, Chen ZS, et al. Thyroid hormone disorders: a predictor of mortality in patients with septic shock defined by Sepsis-3?[J]. Intern Emerg Med, 2021, 16(4): 967-973.
[33] Foks M, Dudek A, Polok K, et al. Thyroid hormones as potential prognostic factors in sepsis[J]. Anaesthesiol Intensive The, 2019, 51(3): 205-209.
[34] Kothiwale VA, Patil P, Gaur S. Correlation of thyroid hormone profile with the acute physiology and chronic health evaluation Ⅱ score as a prognostic marker in patients with sepsis in the intensive care unit[J]. J Assoc Physicians India, 2018, 66(7): 59-62.
[35] Li X, Zhu Z, Zhou T, et al. Predictive value of combined serum FGF21 and free T3 for survival in septic patients[J]. Clin Chim Acta, 2019, 494: 31-37.
[36] Inan M, Koyuncu A, Aydin C, et al. Thyroid hormone supplementation in sepsis: an experimental study[J]. Surg Today, 2003, 33(1): 24-29.
[37] 詹峰, 宋维, 陈文腾, 等. 小剂量左旋甲状腺素干预严重脓毒症合并正常甲状腺功能病态综合征患者疗效观察[J]. 中国急救医学, 2017, 37(2): 105-108.
[38] Frau C, Godart M, Plateroti M. Thyroid hormone regulation of intestinal epithelial stem cell biology[J]. Mol Cell Endocrinol, 2017, 459: 90-97.
[39] Shirali AS, Wu JX, Zhu CY, et al. The role of serum procalcitonin in predicting bacterial sepsis in patients with hypothyroidism[J]. J Clin Endocrinol Metab, 2019, 104(12): 5915-5922.
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