Journal of Internal Medicine Concepts & Practice ›› 2023, Vol. 18 ›› Issue (03): 215-220.doi: 10.16138/j.1673-6087.2023.03.017
• Review article • Previous Articles Next Articles
ZHANG Ruixiang, SUN Shuoshuo, WEI Xiao(
), et al
Received:2022-11-01
Online:2023-06-30
Published:2023-08-07
CLC Number:
ZHANG Ruixiang, SUN Shuoshuo, WEI Xiao, et al . Application of lipid-modulating drugs in treatment of non-alcoholic fatty liver disease[J]. Journal of Internal Medicine Concepts & Practice, 2023, 18(03): 215-220.
| 药物类别 | 药品名 | 脂代谢影响 | 主要不良反应 | 改善NAFLD的潜在机制 | ||||
|---|---|---|---|---|---|---|---|---|
| 改善脂肪变性 | 抗炎 | 抗氧化应激 | 抗纤维化 | 降低肝酶 | ||||
| 他汀类药物[ | 阿托伐他汀 辛伐他汀 瑞舒伐他汀 | TC↓ TG↓ HDL-C↑ | 肝功能异常、肌痛、肌炎和 横纹肌溶解 | + | + | + | +/- | + |
| 胆固醇吸收抑制剂[ | 依折麦布 | LDL-C↓ | 头疼和消化道症状 | + | + | + | - | - |
| BAS[ | 考来烯胺 考来维仑 | TC↓ TG↓ LDL-C↓ | 胃肠道不适、便秘和影响 某些药物的吸收 | + | + | - | + | - |
| 贝特类药物[ | 非诺贝特 | TG↓ LDL-C↓ HDL-C↑ | 肝脏、肌肉和肾毒性 | + | + | + | + | - |
| 高纯度鱼油制剂[ | n-3 PUFA | TG↓ | 消化道症状，少数病例出现 转氨酶或肌酸激酶轻度升高 | + | + | - | - | + |
| PCSK9抑制剂[ | 阿利西尤单抗 依洛尤单抗 | LDL-C↓ HDL-C↑ | 无严重不良反应报道 | + | - | - | - | + |
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