Application of endoscopic retrograde cholangiopancreatography in treatment of adolescent patients with chronic pancreatitis and complications

doi:10.16138/j.1673-6087.2025.03.03

Abstract

Abstract:

Objective To explore the clinical application value of endoscopic retrograde cholangiopancreatography (ERCP) in the treatment of chronic pancreatitis and its complications in adolescents. Methods The clinical data of 104 adolescent patients with chronic pancreatitis and complications who were admitted to the Department of Gastroenterology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine from January 2023 to December 2024 were collected and a retrospective analysis was conducted. The patients were divided into the ERCP group (receiving ERCP treatment) and the control group (receiving conventional treatment) based on the treatment methods. The treatment effects, safety indicators, recurrence rates within six months, and scores of quality of life were compared between the two groups. Results There were 68 cases in the ERCP group and 36 cases in the control group. The two groups showed no significant differences in age, disease characteristics, and pre-treatment visual analogue scale (VAS) scores (P=0.080, 0.386, and 0.185, respectively), while the difference in 12-item short form health survey (SF-12) scores before treatment were significant (P=0.025). Before treatment, the VAS scores of the two groups were 6.63±1.74 and 6.26±1.08, respectively (P>0.05). After treatment, the VAS score in the ERCP group (2.57±0.64) was significantly lower than that in the control group (4.63±0.79) (P<0.001). Before treatment, the SF-12 scores of the two groups were 44.57±8.09 and 49.36±11.02, respectively (P>0.05); after treatment, the SF-12 score in the ERCP group (84.65±9.27) was significantly higher than that in the control group (69.16±7.75) (P<0.001). In addition, the recurrence rates within six months were 14.08% (ERCP group) and 36.11% (control group), and complication rates were 1.47% (ERCP group) and 8.33% (control group), which showed significant differences. Conclusions For adolescent patients with cholangiopancreatography and its complications, ERCP (especially pancreatic duct stone removal and stent placement) effectively alleviates clinical symptoms, improves quality of life, and shows high success rates with a low incidence of complications.

Key words: Pancreatic duct stone removal, Stent placement, Pain relief in pancreatitis, Adolescent patients

CLC Number:

R576

HUANG Yun, BIELIKE Kouken, HUANG Jia, YAO Weiyan, ZHU Yin. Application of endoscopic retrograde cholangiopancreatography in treatment of adolescent patients with chronic pancreatitis and complications[J]. Journal of Internal Medicine Concepts & Practice, 2025, 20(03): 198-203.

Figures/Tables 4

Table 1

Figure 1

Table 2

Comparison of VAS scores between the two groups of patients（score，$ \bar{x} \pm s $）

组别	治疗前	治疗后	t	P
对照组（n=36）	6.26 $±$ 1.08	4.63 $±$ 0.97	6.373	0.000
ERCP组（n=68）	6.63 $±$ 1.74	2.57 $±$ 0.46^1）	72.360	0.000

Table 2

Table 3

Comparison of SF-12 scores between the two groups of patients（score，$ \bar{x} \pm s $）

组别	治疗前	治疗后	t	P
对照组（n=36）	49.36 $±$ 11.02	69.16 $±$ 7.75	8.180	0.000
ERCP组（n=68）	44.57 $±$ 8.09^1）	84.65 $±$ 9.27^1）	26.863	0.000

Table 3

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特征	ERCP组（n=68）	对照组（n=36）	U	P
年龄(岁)	31（24，35）	34（27，37）	-0.264	0.080
男性[n(%)]	53（77.94）	30（83.33）	-	0.613
病程(月)	36（12，72）	36（15，120）	-0.866	0.386
胰管形态改变[n(%)]	24（35.29）	27（75.00）	-	0.293
胰管结石并胰管改变[n(%)]	31（45.59）	10（27.78）	-	0.094
胰腺钙化[n(%)]	5（7.35）	12（33.33）	-	0.099
胰腺囊肿[n(%)]	4（5.88）	4（11.11）	-	0.443