Application of mesenchymal stem cells in systemic rheumatic diseases: current situation and prospects

doi:10.16138/j.1673-6087.2024.06.13

Abstract

Abstract:

Mesenchymal stem cell (MSC), a type of cell with the ability to differentiate into multiple lineages and immunomodulatory properties, have gained widespread attention in the treatment of systemic rheumatic diseases recently. Systemic rheumatic diseases such as systemic lupus erythematosus, rheumatoid arthritis, ankylosing spondylitis, and Sjögren syndrome often led to a significant decline in patients’ quality of life, while current treatment methods have limitations. Therefore, it’s important to explore new method, and the application of MSC in these diseases has great significance. Current research indicates that MSC can exert therapeutic effects through various mechanisms, including regulating immune responses, promoting tissue repair, and reducing inflammation, and some clinical studies have showed the potential efficacy of MSC in systemic rheumatic diseases. However, many issues still need to be addressed, such as the source of cells, optimization of treatment protocols, and long-term safety assessments. This article systematically reviews the current application status of MSC in systemic rheumatic diseases, analyze their efficacy, safety, and future research directions, to provide a reference for development in this field.

Key words: Mesenchymal stem cell, Systemic rheumatic diseases, Systemic lupus erythematosus, Sjögren syndrome

CLC Number:

R593.2

SU Chuanxin, ZHU Zhenhang, WANG Wang, LIANG Rongzhen, ZHENG Songguo, ZHAO Futao. Application of mesenchymal stem cells in systemic rheumatic diseases: current situation and prospects[J]. Journal of Internal Medicine Concepts & Practice, 2024, 19(06): 422-426.

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